Gene: [10q243/PYCS] pyrroline-5-carboxylate synthetase, delta 1-; glutamate 5-kinase (gamma-glutamyl kinase; GK; EC:2.7.2.11); glutamate-5-semialdehyde dehydrogenase (glutamate gamma-semialdehyde synthetase; GSAS; EC:1.2.1.41);
|
COM |
Jones-1976 assigned the PYCS gene to Chr 10. Liu-1996 refined the location to Chr 10q24.3 by fluorescence in situ hybridization." |
|
FUN |
Delta-1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP-dependent (EC:2.7.2.11) and NADPH-dependent (EC:1.2.1.41) conversion of L-glutamate to glutamic gamma-semialdehyde, which is the metabolic precursor for proline biosynthesis." |
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REF |
CLO,SEQ "Aral B &: CR Acad Sci III, 319, 171-178, 1996 LOC "Jones C &: CCG, 16, 387-390, 1976 LOC,FAG "Jones C &: Somat Cell Genet, 1, 345-354, 1975 LOC "Liu G &: Genomics, 37, 145-146, 1996 |
|
KEY |
aac |
|
CLA |
coding, basic |
|
LOC |
10 q24.3 |
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MIM |
MIM: 138250 |
|
EZN |
ENZYME: 2.7.2.11 |
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