Gene: [10q25/MXI1] MAX-interacting protein 1; prostate cancer 1 (MIM:176807); [PRCA1 ]
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FUN |
The Mxi1 protein functions in a regulatory network with members of the c-Myc family (see GEM:01p32/MYCL1), in which c-Myc activates transcription and stimulates cell proliferation, and Mxi1 negatively regulates these actions. Inactivation of the MXI1 gene could, therefore, inhibit differentiation and enhance proliferation in the presence of normal levels of c-Myc, and thus MXI1 is a potential tumor suppressor gene (Wechsler-1997)." |
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REF |
CLO,SEQ,STR "Albarosa R &: Hum Genet, 95, 709-711, 1995 FOG "Carter BS &: PNAS, 89, N8, 3367-3371, 1992 MUT "Eagle LR &: Nature Genet, 9, 249-255, 1995 LOC "Edelhoff S &: Oncogene, 9, 665-668, 1994 FOG "Edwards A &: Genomics, 12, 241-253, 1992 LIN "Irvine RA &: Cancer Res, 55, 1937-1940, 1995 LOC "Shapiro DN &: Genomics, 23, 282-285, 1994 FUN,EXP "Wechsler DS &: Cancer Res, 57, N21, 4905-4912, 1997 CLO,SEQ,GEN "Wechsler DS &: Genomics, 32, N3, 466-470, 1996 LOC "Wechsler DS &: Genomics, 21, 669-672, 1994 IDN "Zervos AS &: Cell, 72, 223-232, 1993 |
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KEY |
trc, onc |
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CLA |
coding, basic |
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LOC |
10 q25 |
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MIM |
MIM: 600020 |
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SYN |
PRCA1 |
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