Gene: [10q2/NRAP] nebulin-related anchoring protein;
|
COM |
The NRAP gene was mapped to chromosome 10q24-q26 by use of PCR of a radiation hybrid panel (Luo-1997a)." |
|
FUN |
NRAP is localized at the myotendinous junction in skeletal muscle and the intercalated disc in cardiac muscle. It is suggested that NRAP performs an anchoring function, linking the terminal actin filaments of myofibrils to protein complexes located beneath the sarcolemma (Luo-1997b)." |
|
PRT |
"Sequence analysis predicted that NRAP is a 1,175-amino acid protein
with a pI of 9.26. The C-terminal half of NRAP includes an actin-binding domain with homology to the nebulin super repeats. The N-terminal region contains a LIM domain, thought to mediate protein-protein interactions (Luo-1997b)." |
|
FAG |
Nebulin is a family of giant myofibrillar proteins found within the sarcomeres of skeletal muscle. The main nebulin gene has been mapped to Chr 2q24 (GEM:02q24/NEB)." |
|
REF |
LOC,EAG "Luo G &: Genomics, 45, 229-232, 1997a MOU,COD,EXP,FUN "Luo G &: Cell Motil Cytoskeleton, 38, 75-90, 1997b |
|
KEY |
myo |
|
CLA |
coding, basic |
|
LOC |
10 q24-26 |
|
MIM |
MIM: 602873 |
