Gene: [11p151/LDHA] lactate dehydrogenase A (M chain; muscle); exertional myoglobinuria (lactate dehydrogenase A deficiency);
|
GEN |
The gene length is 12 kb. |
|
FUN |
Systematic name: (S)-lactate:NAD+ oxidoreductase. The reaction catalyzed: (S)-lactate + NAD+ = pyruvate + NADH." |
|
FAG |
[1] Five human LDHA-like sequences have been found: GEM:04p1/LDHAL1;
GEM:01q4/LDHAL2; GEM:02^/LDHAL3; GEM:09^/LDHAL4; GEM:10^/LDHAL5.
[2] Two genes coding for other isoforms of lactate dehydrogenase (GEM:12p12/LDHB; GEM:11p151/LDHC) and three LDH-like sequences (GEM:13^/LDHBL1; GEM:0X^/LDHBP; and GEM:11p1/LDHCL) have been mapped. According to previous data (Sakai-1987, Edwards-1987, Li-1988) there are three to five other LDH-like sequences in the human genome, which have not been mapped yet." |
|
REF |
LOC,CYG "Boone &: PNAS, 69, 510-514, 1972 SEQ,GEN,FAG "Chung FZ &: Biochem J, 231, 537-541, 1985 MOP,FAG "Edwards &: Dev Genet, 8, 219-232, 1987 PRO,LOC,LIN "Gerhard &: CCG, 46, (HGM9), 619, 1987 FOG,PAT "Kanno &: Clin Chim Acta, 108, 267-276, 1980 LOC,MAP "Lebo RV &: Hum Genet, 69, 316-320, 1985 LOC,MAP "Lewis WH &: Hum Genet, 71, 249-253, 1985 MOP,FAG "Li SS &: CCG, 48, 16-18, 1988 FOG,PAT "Maekawa M &: AJHG, 39, 232-238, 1986 FOG,PAT "Maekawa M &: AJHG, 36, 1204-1214, 1984 MOP,FAG "Sakai &: Biochem J, 242, 619-622, 1987 SEQ,PRO,FAG "Tsujibo H &: Eur J Biochem, 147, 9-15, 1985 LOC,MAP "Van Heyningen &: CCG, 40, (HGM8), 768, 1985 LOC,MAP "Yang-Feng TL &: Hum Genet, 74, 331-334, 1986 |
|
KEY |
glyc, myo |
|
CLA |
coding, basic |
|
LOC |
11 p15.1 |
|
MIM |
MIM: 150000 |
|
EZN |
ENZYME: 1.1.1.27 |
Смотрите также:
