Gene: [11p155/TH] tyrosine hydroxylase;
|
FUN |
[1] The enzyme plays an important role in the the physiology of
adrenergic neurons. It catalyzes the rate-limiting step in
catecholamine biosynthesis.
[2] Systematic name: L-tyrosine,tetrahydropteridine:oxygen oxidoreductase. Catalyzes reaction: L-tyrosine + tetrahydropteridine + O(2) = = 3,4-dihydroxy-L-phenylalanine + dihydropteridine + H(2)O." |
|
REF |
GEN,LOC,MOL,EVO "Craig &: CCG, 42, 29-32, 1986 PRO,LOC,LIN,MOL "Craig &: CCG, 40, (HGM8), 610, 1985 EXP,FUN "Dumas &: J Neurosci Res, 25, N4, 569-575, 1990 CLO,SEQ,EXP "Grima B &: Nature, 326, 707-711, 1987 CLO,SEQ,EXP "Grima B &: PNAS, 82, 617-621, 1985 PRO,LOC,LIN,MOL "Jeanpierre &: CCG, 40, (HGM8), 661, 1985 PRO,LOC,LIN,MOL "O'Malley KL, Rotwein: NAR, 16, 4437-4446, 1988 PRO,LOC,LIN,MOL "Xue &: CCG, 46, (HGM9), 721-722, 1987 |
|
KEY |
neu, aac |
|
CLA |
coding, basic |
|
LOC |
11 p15.5 |
|
MIM |
MIM: 191290 |
|
EZN |
ENZYME: 1.14.16.2 |
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