Gene: [11p15/RRM1] ribonucleotide reductase M1 polypeptide;


FUN

[1] The holoenzyme provides the precursors for DNA synthesis. It catalyzes the reactions of interconvertion of ribonucleotide and corresponding deoxyribonucleotides.
[2] Systematic name: 2'-deoxyribonucleoside-diphosphate:oxidized-thio- redoxin 2'-deoxyreductase. Catalyzes reaction: 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H(2)O = = ribonucleoside diphosphate + reduced thioredoxin."

MOP

Ribonucleotide reductase consists of 2 subunits, M1 and M2. It is an iron-sulfur protein."

FAG

The gene coding for ribonucleotide reductase M2 polypeptide is mapped to chr 2 (GEM:02p2/RRM2). Four RRM pseudogenes are localized in chr 1p, 1q, Xp and Xq: GEM:01p3/RRM2P1; GEM:01q2/RRM2P2; GEM:0Xp11/RRM2P3; and GEM:0Xq/RRM2P4."

HIS

The HGM catalogue erroneously indicates EC=1.7.14.1.

REF

PRO,LOC,MOL,EVO "Brissenden JE &: Exp Cell Res, 174, 302-308, 1988
LOC,CYG "Byrne JA &: Cancer Genet Cytogenet, 59, N2, 206-209, 1992
LOC,CYG "Engstrom Y, Francke U: Exp Cell Res, 158, 477-483, 1985

KEY

nucm, repr

CLA

coding, basic

LOC

11 p15

MIM

MIM: 180410

EZN

ENZYME: 1.17.4.1

鸯铗痂蝈 蜞赕:

  • CDP+THREDH = dCDP+THREDH+H2O
  • 膛依廖巳翘 陀仕盼胰奈
  • ADP+THREDH=dADP+THRED+H2O
  • 嫌腥臀论 陀仕盼胰嫩: 膛依廖巳翘
  • 缅睇 痂犷眢觌孱玷滗梏铖羿 疱潴牝噻
  • 门哇 嫌腥臀挛梦 瘟膛屠