Gene: [11p15/RRM1] ribonucleotide reductase M1 polypeptide;
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FUN |
[1] The holoenzyme provides the precursors for DNA synthesis.
It catalyzes the reactions of interconvertion of ribonucleotide and
corresponding deoxyribonucleotides.
[2] Systematic name: 2'-deoxyribonucleoside-diphosphate:oxidized-thio- redoxin 2'-deoxyreductase. Catalyzes reaction: 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H(2)O = = ribonucleoside diphosphate + reduced thioredoxin." |
|
MOP |
Ribonucleotide reductase consists of 2 subunits, M1 and M2. It is an iron-sulfur protein." |
|
FAG |
The gene coding for ribonucleotide reductase M2 polypeptide is mapped to chr 2 (GEM:02p2/RRM2). Four RRM pseudogenes are localized in chr 1p, 1q, Xp and Xq: GEM:01p3/RRM2P1; GEM:01q2/RRM2P2; GEM:0Xp11/RRM2P3; and GEM:0Xq/RRM2P4." |
|
HIS |
The HGM catalogue erroneously indicates EC=1.7.14.1. |
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REF |
PRO,LOC,MOL,EVO "Brissenden JE &: Exp Cell Res, 174, 302-308, 1988 LOC,CYG "Byrne JA &: Cancer Genet Cytogenet, 59, N2, 206-209, 1992 LOC,CYG "Engstrom Y, Francke U: Exp Cell Res, 158, 477-483, 1985 |
|
KEY |
nucm, repr |
|
CLA |
coding, basic |
|
LOC |
11 p15 |
|
MIM |
MIM: 180410 |
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EZN |
ENZYME: 1.17.4.1 |
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