Gene: [11q13/CAPN1] calpain, large polypeptide L1 (catalytic); calcium-activated neutral proteinase Mu;
|
COM |
Calpain inhibitor (calpastatin) was mapped to Chr 5q (GEM:05q/CAST). |
|
FUN |
[1] Calpain belongs to the group of cysteine proteinases. It is a
heterodimer consisting of the large (L) and small (S) subunits
(GEM:19q131/CAPN4). L peptides are encoded
by three genes CAPN1,
GEM:01^/CAPN2, and GEM:15q15/CAPN3.
[2] The preferential cleavage: Tyr-|-Xaa, Met-|-Xaa or Arg-|-Xaa with Leu or Val as the p2 residue." |
|
REL |
GEM:00.0/CAPN5; GEM:00.0/CAPN6. |
|
REF |
PRO,LOC "Ohno S &: CCG, 53, 225-229, 1990 PRO,MOP,LOC "Ohno S &: CCG, 51, (HGM10), 1054-1055, 1989 LOC "Sawicki M &: Genomics, 42, N3, 405-412, 1997 FUN "Zhang W &: JBC, 271, N31, 18825-18830, 1996 |
|
KEY |
pep |
|
CLA |
coding, basic |
|
LOC |
11 q13 |
|
MIM |
MIM: 114220 |
|
EZN |
ENZYME: 3.4.22.17 |
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