Gene: [11q13/FTH1] ferritin, heavy polypeptide 1; [FTHL6 FTH ]
|
GEN |
[1] The gene length is 3 kb. Exons: 4 (114 bp/38 amino acids, 126 bp/42
amino acids, 162 bp/54 amino acids); introns: 3 (1st - 1.65 kb,
between 331st and 332nd base pairs of cDNA; 2nd - 0.256 kb, between
478th and 479th base pairs; 3d - 0.096 kb, between 604th and 605th
base pairs).
[2] The primary translation product consists of 183 amino acid residues." |
|
FUN |
Ferritin is the basic intracellular protein that serves for storage and transport of iron ions." |
|
FAG |
The gene for the light subunit of ferritin is mapped to chr 19 (GEM:19q133/FTL). Two FTL-like sequences are also mapped GEM:20q1/FTLL1, GEM:0Xp2/FTLL2)." |
|
HIS |
The contradictory data on the localization of FTH gene in chrs 1 and 19 (McGill-1984; Caskey-1983) are explained now by the presence of multiple FTH pseudogenes and FTH-like sequences in various chromosomes." |
|
PSG |
A FTH pseudogene and over 10 FTH-like sequences dispersed among various chromosomes are currently mapped: GEM:01p/FTHL1; GEM:01q/FTHL2; GEM:02q3/FTHL3; GEM:03q2/FTHL4; GEM:13q12/FTHL7; GEM:0Xq2/FTHL8; GEM:05^/FTHL10; GEM:08^/FTHL11; GEM:09^/FTHL12; GEM:14^/FTHL13; GEM:17^/FTHL14; GEM:06p1/FTHL15; GEM:11q13/FTHL16; GEM:06p/FTHP1. Two more pseudogenes are registered: GEM:00.0/FTHP2 and GEM:00.0/FTHP3." |
|
REF |
CLO,SEQ,EXP "Boyd D &: PNAS, 81, 4751-4755, 1984 HIS,LOC,MOL,CYG,FAG "Caskey &: PNAS, 80, 482-486, 1983 GEN,SEQ,EXP,LOC,FAG "Costanzo F &: NAR, 14, 721-736, 1986 LOC,MOL,CYG,FAG "Cragg &: Hum Genet, 71, 108-112, 1985 GEN,SEQ,EXP,LOC,FAG "Dorner MH &: PNAS, 82, N10, 3139-3143, 1985 LOC,MOL,CYG,FAG "Gatti RA &: AJHG, 41, 654-667, 1987a LOC,MOL,CYG,FAG "Gatti RA &: CCG, 46, (HGM9), 618, 1987b GEN,SEQ,EXP,LOC,FAG "Hentze MW &: PNAS, 83, N19, 7226-7230, 1986 GEN,SEQ,EXP,LOC,FAG "Jain SK &: JBC, 260, N21, 11762-11768, 1985 REV,EXP,FAG "McGill JR &: Hum Genet, 76, 66-72, 1987 LOC,MOL,CYG,FAG "McGill JR &: CCG, 40, (HGM8), 696-697, 1985 HIS,LOC,MOL,CYG,FAG "McGill JR &: AJHG, 36, 146S, 1984 GEN,EVO,RAT "Murray &: PNAS, 84, N21, 7438-7442, 1987 LOC,MOL,CYG,FAG "Worwood M &: Hum Genet, 69, 371-374, 1985 |
|
KEY |
trp, ion |
|
CLA |
coding, basic |
|
LOC |
11 q13 |
|
MIM |
MIM: 134770 |
|
SYN |
FTHL6 FTH |
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