Gene: [11q13/FTH1] ferritin, heavy polypeptide 1; [FTHL6 FTH ]


GEN

[1] The gene length is 3 kb. Exons: 4 (114 bp/38 amino acids, 126 bp/42 amino acids, 162 bp/54 amino acids); introns: 3 (1st - 1.65 kb, between 331st and 332nd base pairs of cDNA; 2nd - 0.256 kb, between 478th and 479th base pairs; 3d - 0.096 kb, between 604th and 605th base pairs).
[2] The primary translation product consists of 183 amino acid residues."

FUN

Ferritin is the basic intracellular protein that serves for storage and transport of iron ions."

FAG

The gene for the light subunit of ferritin is mapped to chr 19 (GEM:19q133/FTL). Two FTL-like sequences are also mapped GEM:20q1/FTLL1, GEM:0Xp2/FTLL2)."

HIS

The contradictory data on the localization of FTH gene in chrs 1 and 19 (McGill-1984; Caskey-1983) are explained now by the presence of multiple FTH pseudogenes and FTH-like sequences in various chromosomes."

PSG

A FTH pseudogene and over 10 FTH-like sequences dispersed among various chromosomes are currently mapped: GEM:01p/FTHL1; GEM:01q/FTHL2; GEM:02q3/FTHL3; GEM:03q2/FTHL4; GEM:13q12/FTHL7; GEM:0Xq2/FTHL8; GEM:05^/FTHL10; GEM:08^/FTHL11; GEM:09^/FTHL12; GEM:14^/FTHL13; GEM:17^/FTHL14; GEM:06p1/FTHL15; GEM:11q13/FTHL16; GEM:06p/FTHP1. Two more pseudogenes are registered: GEM:00.0/FTHP2 and GEM:00.0/FTHP3."

REF

CLO,SEQ,EXP "Boyd D &: PNAS, 81, 4751-4755, 1984
HIS,LOC,MOL,CYG,FAG "Caskey &: PNAS, 80, 482-486, 1983
GEN,SEQ,EXP,LOC,FAG "Costanzo F &: NAR, 14, 721-736, 1986
LOC,MOL,CYG,FAG "Cragg &: Hum Genet, 71, 108-112, 1985
GEN,SEQ,EXP,LOC,FAG "Dorner MH &: PNAS, 82, N10, 3139-3143, 1985
LOC,MOL,CYG,FAG "Gatti RA &: AJHG, 41, 654-667, 1987a
LOC,MOL,CYG,FAG "Gatti RA &: CCG, 46, (HGM9), 618, 1987b
GEN,SEQ,EXP,LOC,FAG "Hentze MW &: PNAS, 83, N19, 7226-7230, 1986
GEN,SEQ,EXP,LOC,FAG "Jain SK &: JBC, 260, N21, 11762-11768, 1985
REV,EXP,FAG "McGill JR &: Hum Genet, 76, 66-72, 1987
LOC,MOL,CYG,FAG "McGill JR &: CCG, 40, (HGM8), 696-697, 1985
HIS,LOC,MOL,CYG,FAG "McGill JR &: AJHG, 36, 146S, 1984
GEN,EVO,RAT "Murray &: PNAS, 84, N21, 7438-7442, 1987
LOC,MOL,CYG,FAG "Worwood M &: Hum Genet, 69, 371-374, 1985

KEY

trp, ion

CLA

coding, basic

LOC

11 q13

MIM

MIM: 134770

SYN

FTHL6 FTH

Смотрите также:

  • HUGEN-ферритин