Gene: [11q1/CD20] antigen CD20 (lymphocyte differentiation antigen B1/1F5); [1F5/B1 B1/1F5 ]
|
EXP |
[1] Antigene B1, also known as CD20, is a human B-lymphocyte surface
molecule
that is widely expressed during B-cell ontogeny, from early pre-B-cell
developmental stages until final differentiation into plasma cells.
Although the exact role of B1 in vivo is unknown, functional studies
using monoclonal antibodies have shown that antibody binding to B1
inhibits B-cell proliferation caused by mitogens and inhibits B-cell
differentiation.
[2] Only the CD20 mAb was found to suppress the spontaneous apoptosis which occurs in human germinal center (GC) B cells when placed in tissue culture at 37 degrees C (Holder-1995)." |
|
GEN |
The gene length is 16 kb; exons: 8 (Tedder-1989b). Three mRNA fractions corresponding to this gene exist: a major one (2.8 kb) and two minor ones (2.6 and 3.4 kb) (Tedder-1988)." |
|
LIK |
GEM:11q1/CD20L. |
|
REF |
CLO,SEQ,EXP,MOP,EVO "Einfeld DA &: EMBO J, 7, N3, 711-717, 1988 EXP,FUN "Holder M &: Eur J Immunol, 25, N11, 3160-3164, 1995 IDN,FUN "Stashenko P &: J Immunol, 125, N4, 1678-1685, 1980 LIN,MAF "Szepetowski P &: Genomics, 16, 745-750, 1993 PRO,LOC "Tedder TF &: J Immunol, 142, N7, 2555-2559, 1989a CLO,GEN,SEQ,EXP,MOP "Tedder TF &: J Immunol, 142, N7, 2560-2568, 1989b CLO,SEQ,EXP,MOP,EVO "Tedder TF &: J Immunol, 141, N12, 4388-4394, 1988a CLO,SEQ,EXP,MOP,EVO "Tedder TF &: Mol Immunol, 25, N12, 1321-1330, 1988b CLO,SEQ,EXP,MOP,EVO "Tedder TF &: PNAS, 85, N1, 208-212, 1988c |
|
KEY |
mem, imm |
|
CLA |
coding, basic |
|
LOC |
11 q12-13.1 |
|
MIM |
MIM: 112210 |
|
SYN |
1F5/B1 B1/1F5 |
