Gene: [11q22/MMP20] matrix metalloproteinase 20 (enamelysin);
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COM |
MMP20 is mapped to Chr 11q22, clustered to at least seven other members of the MMP gene family (Llano-1997)." |
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FUN |
The recombinant human enamelysin is able to degrade amelogenin, the major protein component of the enamel matrix (on genes for amelogenin see GEM:0Yp112/AMELY; GEM:0Xp22/AMELX). On the basis of its degrading activity on amelogenin, and its highly restricted expression to dental tissues, human enamelysin is suggested to play a central role in the process of tooth enamel formation (Llano-1997)." |
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MOP |
Human enamelysin (MMP-20) has a domain organization similar to other MMPs, including a signal peptide, a prodomain with the conserved motif PRCGVPD involved in maintaining enzyme latency, a catalytic domain with a Zn-binding site, and a COOH-terminal fragment similar to the sequence of hemopexin. The calculated molecular mass of human enamelysin is about 54 kDa, which is similar to that of collagenases or stromelysins (Llano-1997)." |
|
REF |
COD,SEQ,FUN "Llano E &: Biochemistry, 36, N49, 15101-15108, 1997 |
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KEY |
pep, exce |
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CLA |
coding, basic |
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LOC |
11 q22 |
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MIM |
? |
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EZN |
ENZYME: 3.4.24.? |
