Gene: [11q2/FDX1] ferredoxin 1 (adrenodoxin; adrenal ferredoxin); [FDX ADX ]
PRO | Lambda-HADX-7 probe contains an insert of full-size cDNA (1250 bp). The probe reveals the following hybridization fragments: In PstI hydrolyzate, 16 and 3.8 kb (strong signal) and 3.2 and 2.4 kb (weak signal); in HindIII hydrolyzate, 12.5, 10, and 8.3 kb (strong signal) and 9 and 2 kb (weak signal)." |
EXP | Several types of FDX mRNA were found, their sizes falling within an interval 1.0-3.8 kb. All processed transcripts belong to a single coding gene; its primary pro-mRNA contains multiple polyadenilation sites." |
FUN | Fe,S-containing protein ferredoxin is an intermediate electron transfer protein for all cytochrome P450 types involved in steroidogenesis (20- and 22-hydroxilation, splitting of the side chain of cholesterol, and 11-hydroxilation). It does not participate in electron transfer to microsomal cytochromes P450 (17- and 21-hydroxilases, aromatase, etc.)." |
TIS | The protein is synthesized in both steroidogenous (adrenal glands, gonads, placenta) and other tissues." |
FAG | In somatic hybrid cell (mouse-human) culture, 12.5- and 8.3-kb HindIII and 16-kb PstI fragments segregate together with chr 11 and contain a coding FDX gene, whereas 10-kb HindII and 3.8-kb PstI fragments segregate together with chr 20 and contain a processed (deprived of introns) pseudogene FDXP1 (GEM:20q1/FDXP1). Another pseudogene is mapped to chr 21 (GEM:21^/FDXP2)." |
REL | GEM:00.0/FDX2; GEM:20q1/FDXP1; GEM:21^/FDXP2; GEM:17q2/FDXR |
REF | GEN,SEQ,LOC,FAG,EVO
"Chang CY &: DNA Cell Biol, 9, 205-212, 1990 COD,SEQ "Mittal S &: Arch Biochem Biophys, 264, 383-391, 1988 LOC,PRO,FAG "Morel Y &: AJHG, 43, 52-59, 1988 PRO,SEQ "Picado-Leonard J &: JBC, 263, 3240-3244, 1988 LOC "Sparkes RS &: DNA Cell Biol, 10, 359-365, 1991 EXP,MEB "Voutilainen &: J Clin Endocrinol Metab, 66, 383-388, 1988 |
SWI | SWISSPROT: P10109 |
KEY | mito, lip |
CLA | coding, basic |
LOC | 11 q22-23 |
MIM | MIM: 103260 |
SYN | FDX ADX |
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