Gene: [11q2/NCAM1] neural cell adhesion molecule 1 (CD56); [NCAM CD56 ]


MOP

The product is a membrane glycoprotein found in neurons and glial cells. There are several isoforms of it, the main ones weighing 180 kD (a 7.2-kb transcript), 140 kD (a 6.7-kb transcript), and 120 kD. They are products of the alternative splicing of a common precursor."

EVO

Extracellular N-terminal region of the protein product (about 500 amino acid residues) shows a high homology with proteins of immunoglobulin superfamily."

REL

GEM:00.0/NCAM2.

REF

CLO,COD,SEQ,EXP "Barton CH &: Development, 104, 165-173, 1988
TRC,PEP,MOP,EXP "Cunningham &: Science, 236, 799-806, 1987
SEQ,MOP,EXP,FUN "Dickson G &: Cell, 50, 1119-1130, 1987
ENG,FUN,EXP "Doherty &: J Cell Biol, 109, (Aug), 789-798, 1989
SEQ,MOP,EXP,FUN "Gower HJ &: Cell, 55, 955-964, 1988
MOP,EXP,FUN "Moore &: J Cell Biol, 105, 1377-1386, 1987
LOC,MOL "Nguyen C &: J Cell Biol, 102, 711-715, 1986
MOP,EXP,FUN "Nybroe &: Neurochem Int, 12, 251-262, 1988
MOP,EXP,FUN "Prentice &: EMBO J, 6, N7, 1859-1863, 1987
LOC "Telatar M &: Mammal Genome, 6, 59-60, 1995
POL "Telatar M &: Hum Mol Genet, 3, 842, 1994
TRC,PEP,MOP,EXP "Thompson &: Genes Dev, 3, 348-357, 1989
MOP,EXP,FUN "Walsh FS &: Development, 105, 803-811, 1989
TRC,PEP,MOP,EXP "Walsh FS: Neurochem Int, 12, 262-267, 1988
CLO,COD,SEQ,EXP,LOC "Walsh FS &: Mol Brain Res, 1, 197-200, 1986

SWI

SWISSPROT: P13591; NCA2 P13592

KEY

neu, img, mem

CLA

coding, basic

LOC

11 q23-24

MIM

MIM: 116930

SYN

NCAM CD56

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