Gene: [13p12/D13FB2S1] satellite DNA, beta, NOR1-flanking subset 1; [D13F39S1 ]
|
SUM |
[1] This type of Sau3A-repeats was discovered in the laboratory of
H.F.Willard (Dept Med Genet, Univ Toronto, Canada) as a beta-satellite
type. Canonical monomer was shown to contain 68 bp. Individual
loci of these DNA repeats consist of multimers arranged in tandems.
B1 family (clone pB3) has only one location site, within the 9qh
region (the heterochromatic region of a secondary constriction in
the long arm of Chr 9; D9Z5). B2 family (clone pB4 [GDB :181335]) was shown
to be
located on all chromosomes containing nucleolar organizers (Chr 13,
14, 15, 21, and 22). B2 sequences flank rRNA genes at both sides. The
consensus nucleotide sequence of Sau3A monomer is as follows:
[2]-<1=gatcagtgca gagatatgtc acaa(a/t)gcccc (c/-)tgtaggcag agcctagaca= =agagttacat ccacctgggt=70/69?>. [3] In E.D.Sverdlov's laboratory (Inst Bioorganic Chemistry, Moscow, Russia), B2 family was shown to be species-specific due to the fact that the family was revealed (by the Kunkel's method of differential hybridization) in the human genome but not in the chimpanzee genome." |
|
REF |
PRO,SEQ,EVO "Lisitsyn N &: Dokl Akad Nauk SSSR, 312, N4, 983-985, 1990 PRO,SEQ,LOC,FAG "Waye JS, Willard HF: PNAS, 86, N16, 6250-6254, 1989 |
|
KEY |
mgm |
|
CLA |
psi, basic |
|
LOC |
13 p12 |
|
MIM |
? |
|
SYN |
D13F39S1 |
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