Gene: [16p112/SPN] sialophorin (leukosialin; protein gpL115); antigen CD43 (leukocyte sialoglycoprotein); [GPL115 CD43 ]


COM

SPN gene was mapped to Chr 16p11.2 in two independent studies (Shelley-1988; Pallant-1989)."

FAG

The gene for sialophorin was previously supposed (Parkman-1981; Remold-O'Donnell-1984) to be located in Chr X, because abnormal forms of this protein was pathogenetically related to X-linked immunodeficiency syndrome 2 (Wiskott-Aldrich syndrome; GEM:0Xp112/WAS). Presently, it is the sialophorin expression factor that is assumed to be located in Chr X."

REF

PRO,SEQ,EXP,LOC "Pallant A &: PNAS, 86, N4, 1328-1332, 1989
FUN,PAT,COM "Parkman &: Lancet, 2, 1387-1389, 1981
FUN,PAT,COM "Remold-O'Donnell E &: J Exp Med, 159, 1705-1723, 1984
GEN,SEQ,EVO "Shelley CS &: Biochem J, 270, N3, 569-576, 1990
PRO,SEQ,EXP,LOC "Shelley CS &: PNAS, 86, N8, 2819-2823, 1989
PRO,SEQ,EXP,LOC "Shelley CS &: FASEB J, 2, A1659, 1988

SWI

 SWISSPROT: P16150

KEY

mem, imm

CLA

coding, basic

LOC

16 p11.2

MIM

 MIM: 182160

SYN

GPL115 CD43