Gene: [16p133/AXIN1] axin;
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FUN |
Axin is a negative regulator of embryonic axis formation in vertebrates, which acts through a Wnt signal transduction pathway involving the serine/threonine kinase GSK-3 (see GEM:00.0/GSK3A) and beta-catenin (GEM:03p213/CTNNB1). Axin has been shown to have distinct binding sites for GSK-3 and beta-catenin and to promote the phosphorylation of beta-catenin and its consequent degradation. This provides an explanation for the ability of Axin to inhibit signaling through beta-catenin. In addition, a more N-terminal region of Axin binds to adenomatous polyposis coli (GEM:05q2/APC), a tumor suppressor protein that also regulates levels of beta-catenin (Hsu-1999)." |
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REL |
GEM:00.0/AXIN2. |
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REF |
COD,EVO "Hsu W &: JBC, 274, N6, 3439-3445, 1999 COD,EVO,LOC "Zeng L &: Cell, 90, 181-192, 1997 |
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KEY |
ont, onc, sign |
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CLA |
coding, basic |
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LOC |
16 p13.3 |
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MIM |
? |
