Gene: [17q1/TRAF4] receptor-associated factor 4 (malignant 62); cysteine-rich domain associated with RING and TRAF domains (CART1); [MLN62 CART1 ]


COM

The TRAF4 gene was mapped to Chr 17q11-12 by radioisotopic in situ hybridization (Tomasetto-1995)."

FUN

The CART1 protein appears to be involved in TNF-related cytokine signal transduction in breast carcinoma."

GEN

The gene length: 5.5 kb (approximately); exons: 7 (Regnier-1995).

MOP

TRAF4 encodes a predicted 470-amino acid protein that has an unusual RING finger motif at the N terminus, a cysteine-rich domain, called a CART motif, more centrally located, and a TRAF domain at the C terminus (Regnier-1995)."

REF

COD,SEQ,DOM,EVO "Regnier CH &: JBC, 270, N43, 25715-25721, 1995
LOC,COD,EXP "Tomasetto C &: Genomics, 28, N3, 367-376, 1995

KEY

onc

CLA

coding, basic

LOC

17 q11-12

MIM

MIM: 602464

SYN

MLN62 CART1

:

  • Gene: [09q3/TRAF1] receptor-associated factor 1;