Gene: [17q21/JUP] junction plakoglobin (desmoplakin III); [DP3 DP DSP ]
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FUN |
Plakoglobin is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions." |
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FAG |
Plakoglobin associates with the cytoplasmic region of desmoglein I (GEM:18q121/DSG1), one of the transmembrane desmosomal proteins (Mathur-1994). It also is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junction of epithelial cells (Knudsen-1992). Catenins are of central importance for cadherin function in that they mediate the connection of cadherins to actin filaments and are part of a higher order submembranous network by which cadherins are linked to other transmembrane and peripheral cytoplasmic proteins (Aberle-1995). Interaction of the cadherin-catenin complex with epidermal growth factor receptor (see GEM:07p12/EGFR1) and the finding that beta-catenin (GEM:03p213/CTNNB1) and plakoglobin are substrates for tyrosine phosphorylation following EGF stimulation of cells, together with the finding that catenins are associated with the tumor suppressor protein APC (GEM:05q2/APC), open the possibility that catenins are involved in signaling pathways and tumorigenesis." |
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REF |
COD,LOC,EXP "Aberle H &: PNAS, 92, 6384-6388, 1995 COD,LOC,FAG "Arnemann &: Genomics, 10, 640-645, 1991 LOC "Cowley CME &: Hum Genet, 100, N3-4, 486-488, 1997 COD,SEQ,PEP,EVO "Franke WW &: PNAS, 86, 4027-4031, 1989 FUN "Knudsen KA, Wheelock MJ: J Cell Biol, 118, 671-679, 1992 FUN,MEB "Mathur M &: JBC, 269, 14075-14080, 1994 |
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KEY |
mem |
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CLA |
coding, basic |
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LOC |
17 q21 |
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MIM |
MIM: 173325 |
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SYN |
DP3 DP DSP |
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