Gene: [17q/WT4] Wilms tumor supressor 4; Wilms tumor, type IV (familial Wilms tumor 1); [FWT1 ]
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COM |
Rahman-1996 carried out a genome-wide linkage search in a large Canadian family with 7 confirmed cases of WT in 3 generations. The results provided strong evidence for the localization of a familial WT predisposition gene, which they symbolized FWT1, to an 18-cM interval on Chr 17q12-q21. No congenital abnormalities or other cancers had been observed in the family. The average age of presentation was 5 years (age range of 2 to 12 years), which is older than the average age of diagnosis of sporadic WT (3 to 4 years)." |
|
HET |
See GEM:11p13/WT1 |
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REF |
PAT,LOC,LIN "Rahman N &: Nature Genet, 13, 461-463, 1996 |
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KEY |
onc, ren |
|
CLA |
unknown, basic |
|
LOC |
17 q12-21 |
|
MIM |
MIM: 601363 |
|
SYN |
FWT1 |
