Gene: [18q2/TS] thymidylate synthetase (methylenetetrahydrofolate methyltransferase);


FUN

[1] Thymidylate synthetase catalyzes the only pathway for the synthesis of dTMP de novo.
[2] Systematic name: 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase.
[3] Catalyzes reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP."

REF

PRO,GEN,EXP,ENG "Ayusawa &: JBC, 259, N23, 14361-14364, 1984
LOC "Hori T &: CCG, 40, (HGM8), 654-655, 1985a
LOC "Hori T &: Somat Cell Mol Genet, 11, N3, 277-283, 1985b
GEN,SEQ,EXP "Kaneda &: Annu Rep Inst Genet, 39, (Japan), 28-29, 1988a
GEN,SEQ,EXP "Kaneda &: Annu Rep Inst Genet, 39, (Japan), 29, 1988b
LOC "Ledbetter &: AJHG, 36, 203S, 1984
FUN "Nussbaum RL &: AJHG, 37, 1192-1205, 1985
PRO,GEN,EXP,ENG "Takeishi K &: J Biochem, 106, 575-583, 1989
PRO,SEQ,EXP,MOP "Takeishi K &: NAR, 13, 2035-2043, 1985
PRO,GEN,EXP,ENG "Takeishi K &: J Biochem, 95, 1477-1483, 1984

SWI

SWISSPROT: P04818

KEY

repr

CLA

coding, basic

LOC

18 q21.31-t

MIM

MIM: 188350

EZN

ENZYME: 2.1.1.45

Смотрите также:

  • Тимидилатсинтаза (тимидилатсинтетаза)