Gene: [19q132/AD2] Alzheimer disease 2 (APOE*E4-associated, late onset);


COM

A gene for late-onset familial Alzheimer disease maps to the same region as the gene for apolipoprotein E (GEM:19q132/APOE). Corder-1993 found that the risk for AD2 increased from 20 to 90% and mean age of onset decreased from 84 to 68 years with increasing number of E4 alleles of APOE gene."

REF

ASS "Borgaonkar DS &: Lancet, 342, 625, 1993
POL,ASS "Bullido MJ &: Nature Genet, 18, N1, 69-71, 1998
ASS "Corder EH &: Science, 261, 921-923, 1993
ASS "Liddell M &: J Med Genet, 31, 197-200, 1994
HET,LIN,LOC "Pericak-Vance MA &: AJHG, 48, 1034-1050, 1991a
HET,LIN,LOC "Pericak-Vance MA &: CCG, 58, (HGM11), 2024, 1991b
ASS "Strittmatter WJ &: PNAS, 90, 1977-1981, 1993
ASS "van Duijn CM &: AJHG, 55, 714-727, 1994

KEY

neu, mfd

CLA

unknown, basic

LOC

19 q13.2

MIM

MIM: 104310

鸯铗痂蝈 蜞赕:

  • Gene: [21q211/APP] amyloid beta (A4) precursor plaque core protein (cerebral vascular); protease nexin II; Alzheimer disease 1 (MIM:104300); angiopathy, amyloid, congophylic? (cerebral hemorrhage, Dutch type); [CVAP BAP ]
  • Gene: [12^/AD5] Alzheimer disease 5;