Gene: [19q132/PVR] poliovirus receptor (sensitivity); poliomyelitis infection, susceptibility to;


FUN

Nevertheless this marker has been characterized adequately, endogenous functions of the protein are yet unknown."

MOP

[1] Poliovirus receptor belongs to the superfamily of immunoglobulin-like peptides and has the characteristic structure that is common for these peptides: the leader peptide, three extracellular Ig-like genes, the transmembrane domain, and the short variable cytoplasmic domain (Mendelsohn-1989).
[2] It is the poliovirus-specific receptor located on the cell membrane external surface and playing the key role in susceptibility to poliomyelytis that is supposed to be the product of PVS gene. Monoclonal antibodies to the receptor part of this receptor are obtained (D171; Mendehlsohn-1986)."

TIS

Using polyclonal antisera, Freistadt-1990 demonstrated that the poliovirus receptor and poliovirus receptor-like proteins are expressed not only in brain tissues but also in liver, kidney, and intestine. The spectrum of the poliovirus receptor-like protein expression is tissue-specific."

FAG

Two poliovirus receptor related genes have been mapped: GEM:11q2/PVRL1 and GEM:19q13/PVRL2."

REF

HIS,MEB "Bachtold &: Virology, 4, 582-589, 1957
LOC,CYG "Belehradek, Barski: CR Acad Sci Paris, 269, 672-675, 1969
LOC,LIN,CYG "Brook &: CCG, 46, (HGM9), 587, 1987
LOC,CYG "Couillin &: CCG, 46, (HGM9), 599, 1987
LOC,CYG,FAG,EVO "Couillin &: Pathol Biol, 24, 195-203, 1976
EXP,REL,TIS "Freistadt &: Mol Cell Biol, 10, N11, 5700-5706, 1990
HIS,MEB "Holland &: J Exp Med, 110, 65-80, 1959
LIN "Kaneda Y &: PNAS, 81, 3158-3162, 1984
MEB,FAG "Krah, Crowell: Virology, 118, 148-156, 1982
HIS,MEB "McLaren &: J Exp Med, 109, 475-485, 1959
CLO,COD,SEQ,EXP,EVO "Mendelsohn CL &: Cell, 56, 855-865, 1989
FUN,EXP "Mendelsohn CL &: PNAS, 83, N20, 7845-7849, 1986
LOC,CYG "Miller &: Cell, 1, 167-174, 1974
LOC,CYG "Schonk D &: CCG, 54, 15-19, 1990
LOC,CYG "Siddique T &: Genomics, 3, N2, 156-160, 1988
LOC,CYG "Siddique T &: CCG, 46, (HGM9), 692, 1987
LOC,CYG "Siddique T &: CCG, 40, (HGM8), 745, 1985
LOC,CYG "Trask B &: Genomics, 15, 133-145, 1993

KEY

vir, mem, recp, neu, img

CLA

coding, basic

LOC

19 q13.2

MIM

MIM: 173850

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