Gene: [19q133/CGB] chorionic gonadotropin, beta polypeptide;


FAG

[1] Beta subunits of chorionic gonadotropin and luteinizing hormone (GEM:19q133/LHB) are supposed (Boorstein-1982) to be encoded by components of the gene cluster containing at least eight genes (pseudogenes). At least six (Graham-1987) or seven (Talmadge-1983,1984) of them are classified as CGB genes; all of them originate from a single ancestral LHB gene. For details on cloning and expression of CGB/LHB genes, as well as the structure of their peptide products, see the review by W.W.Chin in: Molecular cloning of hormone genes, eds. JF Habener, New Jersey, 1987, p.137-172.
[2] Gene for the chorionic gonadotropin alpha subunit (which is also alpha subunit for three other glycoprotein hormones: thyroid-stimulating, follicle-stimulating, and luteinizing hormones) is located in chr 6q; see GEM:06q/CGA."

REF

LIN,FAG,EAG "Boorstein WR &: Nature, 300, 419-422, 1982
LOC,LIN,MOL "Brook JD &: Hum Genet, 68, 282-285, 1984
CLO,SEQ,MOP "Fiddes JC, Goodman: Nature, 286, 684-687, 1980
CLO,FAG "Graham MY &: NAR, 15, 4437-4448, 1987
LOC,LIN,MOL "Hulsebos &: CCG, 40, (HGM8), 658, 1985
LOC,MOL "Julier C &: Hum Genet, 67, 174-177, 1984
LOC,MOL,FAG "McGill &: CCG, 46, (HGM9), 661, 1985
LOC,MOL,FAG "Naylor SL &: Somat Cell Genet, 9, N6, 757-770, 1983
LIN,FAG,EAG "Policastro PF &: JBC, 261, 5907-5916, 1986
SEQ,GEN,FAG,EXP "Policastro PF &: JBC, 258, N19, 11492-11499, 1983
CLO,FAG,EXP,MOL "Talmadge K &: NAR, 12, N22, 8415-8436, 1984a
LIN,FAG,EAG "Talmadge K &: Nature, 307, 37-40, 1984b
LIN,FAG,EAG "Talmadge K &: DNA, 2, 281-289, 1983

KEY

sex, neu, horm

CLA

coding, basic

LOC

19 q13.3

MIM

MIM: 118860

Смотрите также:

  • Gene: [02p21/LHCGR] luteinizing hormone/choriogonadotropin receptor; male pseudohermaphroditism with Leydig cell hypoplasia/agenesis; gonadotropin unresponsiveness (precocious puberty, familial male; MIM:176410); micropenis; [LCGR ]