Gene: [19q133/CGB] chorionic gonadotropin, beta polypeptide;
|
FAG |
[1] Beta subunits of chorionic gonadotropin and luteinizing hormone
(GEM:19q133/LHB) are supposed (Boorstein-1982)
to be encoded by
components of the gene cluster containing at least eight genes
(pseudogenes). At least six (Graham-1987) or seven
(Talmadge-1983,1984) of them are classified as CGB genes; all of them
originate from a single ancestral LHB gene. For details on cloning and
expression of CGB/LHB genes, as well as the structure of their peptide
products, see the review by W.W.Chin in: Molecular cloning of
hormone genes, eds. JF Habener, New Jersey, 1987, p.137-172.
[2] Gene for the chorionic gonadotropin alpha subunit (which is also alpha subunit for three other glycoprotein hormones: thyroid-stimulating, follicle-stimulating, and luteinizing hormones) is located in chr 6q; see GEM:06q/CGA." |
|
REF |
LIN,FAG,EAG "Boorstein WR &: Nature, 300, 419-422, 1982 LOC,LIN,MOL "Brook JD &: Hum Genet, 68, 282-285, 1984 CLO,SEQ,MOP "Fiddes JC, Goodman: Nature, 286, 684-687, 1980 CLO,FAG "Graham MY &: NAR, 15, 4437-4448, 1987 LOC,LIN,MOL "Hulsebos &: CCG, 40, (HGM8), 658, 1985 LOC,MOL "Julier C &: Hum Genet, 67, 174-177, 1984 LOC,MOL,FAG "McGill &: CCG, 46, (HGM9), 661, 1985 LOC,MOL,FAG "Naylor SL &: Somat Cell Genet, 9, N6, 757-770, 1983 LIN,FAG,EAG "Policastro PF &: JBC, 261, 5907-5916, 1986 SEQ,GEN,FAG,EXP "Policastro PF &: JBC, 258, N19, 11492-11499, 1983 CLO,FAG,EXP,MOL "Talmadge K &: NAR, 12, N22, 8415-8436, 1984a LIN,FAG,EAG "Talmadge K &: Nature, 307, 37-40, 1984b LIN,FAG,EAG "Talmadge K &: DNA, 2, 281-289, 1983 |
|
KEY |
sex, neu, horm |
|
CLA |
coding, basic |
|
LOC |
19 q13.3 |
|
MIM |
MIM: 118860 |
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