Gene: [19q134/IGHAR] Fc fragment of IgA, receptor for; [FCAR CD89 ]
|
COM |
The IGHAR gene for the receptor for the Fc portion of IgA was mapped to 19q13.4 by Southern blot analysis of somatic cell hybrids and in situ hybridization (Kremer-1992)." |
|
FUN |
Human Fc-alpha receptor (FCAR) is present on a number of cell types, including neutrophils, monocytes, macrophages, and eosinophils. FCAR interacts with aggregated IgAs, such as IgA coated on the surface of an invading microorganism, and mediates several immunologic defense processes such as phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators." |
|
MOP |
FCAR is a glycoprotein of 50 to 100 kD, with diversity on different cell types. The predicted FCAR polypeptide of 287 amino acids has 2 Ig-motifs in the extracellular domain and homology to other Fc receptors, including FcGR (see GEM:01q21/IGHGR1A) and FcER (see GEM:01q23/IGHER1A) (Maliszewski-1990)." |
|
GEN |
The gene length: 12 kb; exons: 5 (De Wit-1995). The first 2 exons encode the putative leader peptide, the next 2 exons encode the Ig domains, and the final exon encodes the transmembrane and intracellular domains." |
|
MOP |
In addition to the full-length receptor, neutrophils and eosinophils express an abundant alternatively spliced form of the receptor lacking the fourth exon which encodes the second extracellular Ig motif. Both forms of the receptor bind secretory IgA well (Pleass-1996)." |
|
REF |
GEN,SEQ "De Wit TPM &: J Immunol, 155, 1203-1209, 1995 PRO,LOC,FAG "Kremer EJ &: Hum Genet, 89, 107-108, 1992 COD,SEQ,EXP "Maliszewski CR &: J Exp Med, 172, 1665-1672, 1990 EXP,FUN,PAT "Monteiro RC &: J Clin Invest, 92, 1681-1685, 1993 EXP,MOP "Pleass RJ &: Biochem J, 318, 771-777, 1996 |
|
KEY |
imm, img, recp |
|
CLA |
coding, basic |
|
LOC |
19 q13.4 |
|
MIM |
MIM: 147045 |
|
SYN |
FCAR CD89 |
