Gene: [20q131/YWHAB] tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide (phosphorylated); brain protein 14-3-3, beta subtype (phosphorylated alpha subtype included); [YWHAA ]
COM | [1]
Previously considered a distinctive member of the 14-3-3 family, the alpha
isoform is now included in the beta subtype as the post-transla- tionally
phosphorylated product of the latter (Aitken-1995). [2] For general information about this protein family, see 'Summary' in FAM:BP1433/00.0" |
COD | "<* ="<*" sources="BR" title="{PRT="><** h="/ID:"
mol="%----------------------------------------------------------------------- 'Homo sapiens mRNA for HS1 protein (clone 1054)'; //note: from SV40 transformed MRC-5 fibroblasts (MRC-5 V2)\ /Date: Jul-19-1993\ /Submitted_by: Leffers H (Univ of Aahrus, Inst of Medical Biochemistry, Universitetsparken Bygn 170, DK 8000 Aahrus C, Denmark); //date: Jan-23-1991\ /Duplicated_by: cbi:23113-114\ /Note: The original author remark is as follows:'the protein is related to the protein kinase C inhibitory protein (KCIP) and protein 14-3-3, an activator of tyrosine and tryptophan hydroxylases; is expressed in all the tissues being assayed'\ %----------------------------------------------------------------------- <*** cited="[PROT_DB] '14-3-3 protein beta (protein kinase C inhibitor protein-1, KCIP-1; protein 1054)'\ /Date: Jul-01-1993^Feb-01-1994\ /Duplicated_by: cbi:398954\ /Note_1: There is a confusing remark, in this swp:record:[the protein] 'STRONGLY ACTIVATES protein kinase C'; it is inconsistent with a definition presented above (see the title of the swp:record\ /Note_2: This AA-sequence lacks the first two residues (Met/M and Thr/ T) presented in the other two versions of the sequence; features indicated in this swp:record probably need to be corrected\ /Features: total= 1..244 //note: 14-3-3 protein beta; site= 1 //note: acetylation (putative); site= 58 //note: phosphorylation (putative); site= 63 //note: phosphorylation (putative)\ <**** record="[PIR] '14-3-3 protein (clone 1054) - human'\ /Date: Dec-31-1993 & May-03-1994\ /Duplicated_by: cbi:486668\ %----------------------------------------------------------------------- <* features="BR"><** note="BR"> /Note_1: UTL - UnTransLated segment; CDS - CoDing Segment; TLI - TransLation Initiation; TLT - TransLation Termination; TTS - Transcription Termination Signal (polyA-signal); TCT - TransCription Termination site (polyA-site); pAseq - polyA-sequence\ /Note_2: The following 'Landmarks' and 'Sequence' are derived from 'ref1:' Leffers H &:1993 (emb:X57346)\ <** landmarks="BR"> {seg(1..372) = 5'-UTL(=372); seg(373..1110) = CDS(=738) //note: for 246 amino acids; pos:373 = TLI_1 //note: <_atg> translation START; seg(1111..1213) = 3'-UTL(=103); pos:1111 = TLT_1 //note: <_taa> translation STOP; pos:? = TTS_? //note: not described; pos:1179? = TCT_1? //note: seg(1180..1213) = pAseq} %----------------------------------------------------------------------- <* ="%-------- ref1: 51=ccgccgccgc tgcagccact gcaggcaccg ctgccgccgc ctgagtagtg= ref1: 101=taccgccacc gccgccgccg attccggagc cggggtagtc gccgccgccg= ref1: 151=ccgccgccgc tgcagccact gcaggcaccg ctgccgccgc ctgagtagtg= ref1: 201=ggcttaggaa ggaagaggtc atctcgctcg gagcttcgct cggaagggtc= ref1: 251=tttgttccct gcagccctcc cacggcagag tctccagaga tttgggccgc= ref1: 301=tacaaaaagt gcattttgcc cattcggctg tggatagaga agcaggaaga= ref1: 351=gcactggact tggagtcagg ga=372_ %-------- <** ="%-------- ref1: 373=atg aca atg gat aaa agt gag ctg gta cag aaa gcc aaa ctc gct= pep: 16= E Q A E R Y D D M A A A M K A = ref1: 418=gag cag gct gag cgc tat gat gat atg gct gca gcc atg aag gca= pep: 31= V T E Q G H E L S N E E R N L = ref1: 463=gtc aca gaa cag ggg cat gaa ctc tcc aac gaa gag aga aat ctg= pep: 46= L S V A Y K N V V G A R R S S = ref1: 508=ctc tct gtt gcc tac aag aat gtg gta ggc gcc cgc cgc tct tcc= pep: 61= W R V I S S I E Q K T E R N E = ref1: 553=tgg cgt gtc atc tcc agc att gag cag aaa aca gag agg aat gag= pep: 76= K K Q Q M G K E Y R E K I E A = ref1: 598=aag aag cag cag atg ggc aaa gag tac cgt gag aag ata gag gca= pep: 91= E L Q D I C N D V L E L L D K = ref1: 643=gaa ctg cag gac atc tgc aat gat gtt ctg gag ctg ttg gac aaa= pep:106= Y L I P N A T Q P E S K V F Y = ref1: 688=tat ctt att ccc aat gct aca caa cca gaa agt aag gtg ttc tac= pep:121= L K M K G D Y F R Y L S E V A = ref1: 733=ttg aaa atg aaa gga gat tat ttt agg tat ctt tct gaa gtg gca= pep:136= S G D N K Q T T V S N S Q Q A = ref1: 778=tct gga gac aac aaa caa acc act gtg tcg aac tcc cag cag gct= pep:151= Y Q E A F E I S K K E M Q P T = ref1: 823=tac cag gaa gca ttt gaa att agt aag aaa gaa atg cag cct aca= pep:166= H P I R L G L A L N F S V F Y = ref1: 868=cac cca att cgt ctt ggt ctg gca cta aat ttc tca gtc ttt tac= pep:181= Y E I L N S P E K A C S L A K = ref1: 913=tat gag att cta aac tct cct gaa aag gcc tgt agc ctg gca aaa= pep:196= T A F D E A I A E L D T L N E = ref1: 958=acg gca ttt gat gaa gca att gct gaa ttg gat acg ctg aat gaa= pep:211= E S Y K D S T L I M Q L L R D = ref1:1003=gag tct tat aaa gac agc act ctg atc atg cag tta ctt agg gac= pep:226= N L T L W T S E N Q G D E G D = ref1:1048=aat ctc act ctg tgg aca tcg gaa aac cag gga gac gaa gga gac= pep:241= A G E G E N =246\ ref1:1093=gct ggg gag gga gag aac=1110_ %-------- <** ="%-------- ref1:1161=catatatccc ttgtgcgaT_aaaaaaaaaaa aaaaaaaaaa aaaaaaaaaa= ref1:1211=aaa=1213\" |
REL | GEM:17p13/YWHAE; GEM:00.0/YWHAG; GEM:22q12/YWHAH; GEM:00.0/BP1433TA; GEM:00.0/BP1433TH; GEM:02p25/YWHAZ." |
ECR | "<*
cross-references="[PROT_DB] /Duplicated_by: cbi:398954\ /ID: pir:S34755...........| prt= 246 aa /Date: Dec-31-1993^May-03-1994; /Duplicated_by: cbi:486668\ <* cross-references="[DNA_DB] /Duplicated_by: cbi:23113-114\" |
REF | COM,SYS,PEP,PTM "Aitken A &: JBC, 270, N11 (Mar
17), 5706-5709, 1995 CLO,SEQ,COD,PEP,EXP "Leffers H &: J Mol Biol, 231, N4 (Jun 20), 982-998, 1993 LOC "Tommerup N, Leffers H: Genomics, 33, 149-150, 1996 |
SWI | SWISSPROT: P31946 |
KEY | aac, sign, neu |
CLA | coding, basic |
LOC | 20 q13.1 |
MIM | MIM: 601289 |
SYN | YWHAA |
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