Gene: [21q223/CBFA2] core-binding factor, runt domain, alpha subunit 2 (oncogene Aml1); acute myeloid leukemia 1 (Aml1 oncogene); [AML1 PEBP2A2 ]
COM | Evidence supporting a chromosome 21 locus for acute myelogenous leukemia (AML1) includes the finding of linkage to 21q22.1-q22.2 in a family with a platelet disorder and propensity to develop AML (Ho-1996), an increased incidence of leukemia in Down syndrome, and frequent somatic translocation in leukemia involving the CBFA2 gene." |
HET | Another locus for acute myeloid leukemia is identified: GEM:16q22/AML2. |
REF | POL,LOC "Avramopoulos
D &: Genomics, 15, 98-102, 1993 POL,LOC,LIN "Avramopoulos D &: Genomics, 14, N2, 506-507, 1992 CLO,SEQ "Gao J &: PNAS, 88, 4882-4886, 1991 ABR,FUN "Golub TR &: PNAS, 92, 4917-4921, 1995 PAT,LOC "Ho CY &: Blood, 87, 5218-5224, 1996 LOC "Levanon D &: Genomics, 23, 425-432, 1994 ABR,FUN "Miyoshi H &: NAR, 23, 2762-2769, 1995 CLO,SEQ "Miyoshi H &: PNAS, 88, 10431-10434, 1991 ABR,FUN "Nucifora G &: PNAS, 90, 7784-7788, 1993 REV,ABR "Okuda T &: Cell, 84, 321-330, 1996 |
SWI | SWISSPROT: Q01196 |
KEY | onc, hem |
CLA | coding, basic |
LOC | 21 q22.3 |
MIM | MIM: 151385 |
SYN | AML1 PEBP2A2 |
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