Gene: [22q111/IGLV1] immunoglobulin lambda subunit, variable region 1; amyloidosis idiopathic (primary)?;


MOP

VAR peptides of the immunoglobulin lambda chain are found as sonstituents of so called fibrillar proteins of amyloid, the principal pathogenic marker of primary systemic and myeloma-associated amyloidoses. The pathogenesis of this pathologies remains for most part unclear."

REF

PAT,MOP,PEP "Fykse &: Biochem J, 256, 973-980, 1988
PAT,MOP,PEP "Glenner GG: New Engl J Med, 302, 1283-1292, 1980a
PAT,MOP,PEP "Glenner GG: New Engl J Med, 302, 1333-1343, 1980b
PAT,MOP,PEP "Husby, Sletten: Scand J Immunol, 23, 253-265, 1986
CLO,PRO,LOC "see FAM:IGL/22q11 & FAM:IGLCJ/22q1121

KEY

imm, img

CLA

coding, basic

LOC

22 q11.1

MIM

MIM: 147240

Смотрите также:

  • Gene: [22q111/IGLV2] immunoglobulin lambda subunit, variable region 2;