Gene: [22q133/CELSR1] cadherin EGF LAG seven-pass G-type receptor;
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COM |
The CELSR1 gene was mapped to Chr 22qter by fluorescence in situ hybridization (Hadjantonakis-1997)." |
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MOP |
Celsr1 gene encodes a developmentally regulated vertebrate seven-pass transmembrane protein. The extracellular domain of Celsr1 contains two regions each with homology to distinct classes of well-characterized motifs found in the extra-cellular domains of many cell surface molecules. The most N-terminal region contains a block of contiguous cadherin repeats, and C-terminal to this is a region containing seven epidermal growth factor-like repeats interrupted by two laminin A G-type repeats. Celsr1 is unique in that it contains this combination of repeats coupled to a seven-pass transmembrane domain (Hadjantonakis-1997)." |
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REF |
COD,EAG,LOC "Hadjantonakis AK &: Genomics, 45, 97-104, 1997 |
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KEY |
recp, mem |
|
CLA |
coding, basic |
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LOC |
22 q13.3 |
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MIM |
? |
