Gene superfamily: flavin containing monooxygenases; (FMO1 FMO3 FMO4 FMO5)
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SUM |
Flavin-containing monooxygenases (FMO; EC 1.14.13.8) mediate metabolic N-oxidation of the diet-derived trimethylamine. FMO catalyzes the NADPH-dependent N-oxygenation of nitrogen-, sulfur-, and phosphorus-containing drugs, xenobiotics and endogeneous amines, and is implicated in the detoxification and metabolic activation of environmental toxins. Three forms of the enzyme, FMO1 (GEM:01q2/FMO1) found in fetal liver, FMO3 (GEM:01q2/FMO3) found in adult liver, and FMO4 (GEM:01q2/FMO4) also found in adult liver, are encoded by genes clustered in the 1q23-q25 region." |
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REF |
NOM "Lawton MP &: Arch Biochem Biophys, 308, 254-257, 1994 PRO,LOC,FAG "Shephard EA &: Genomics, 16, 85-89, 1993 MEB,FUN "Ziegler DM: Trends Pharmacol Sci, 11, 321-324, 1990 |
