Gene family: glutamate receptors; (GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRINA GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8)

SUM

Neuronal signals elicited by glutamate are processed by ionotropic (GRI) and metabotropic (GRM) subtypes of receptors. The ionotropic receptor group contains integral cation-specific ion channels and is further subdivided into 2 types, N-methyl-D-aspartate (NMDA) receptors (GRIN) and non-NMDA receptors (GRIA and GRIK). NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GEM:09q343/GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GEM:16p13/GRIN2A), NMDAR2B (GEM:12p12/GRIN2B), NMDAR2C (GEM:17q25/GRIN2C), and NMDAR2D (GEM:19q13/GRIN2D)."