Gene family: glutathione S-transferases; (GSTA1 GSTA2 GSTA3 GSTAP1 GSTAP2 GSTE GSTM1 GSTM1L GSTM2 GSTM3 GSTM4 GSTM5 GSTMS1 GSTMS2 GSTMS3 GSTP1 GSTPP GSTT1 GSTT2)


FUN

Glutathione transferase, being an enzyme of broad substrate specificity, participates in the metabolism of different xenobiotics."

PAT

A relationship of the disturbance of liver isoform (GSTM1) function with the liability to lung cancer in smokers (Seidegard-1986), as well as the GSTA2 deficiency with congenital hyperbilirubinemia (Levi-1969; Board-1981b), were hypothesized."

FAG

[1] Ten human glutathione transferase forms are characterized biochemically and immunologically: three liver forms: GSTA1, GSTA2, GSTM1; the constitutive form, GSTP1 (it is expressed in different tissues, although sometimes it is referred to as the placental form); the muscle form, GSTM2; the cerebral form, GSTM3; the erythrocytic form, GSTE; and the microsomal forms: GEM:12^/GSTMS1; GEM:04q/GSTMS2, GEM:00.0/GSTMS3.
[2] On the basis of phylogenetic comparisons, four GST peptide classes are distinguished: alpha (GSTA1, GSTA2, GSTA3), mu (GSTM1, GSTM2, GSTM3, GSTM4, GSTM5), pi (GSTP1), and theta (GSTT1, GSTT2). GSTE, GSTMS1, GSTMS2, and GSTMS3 are not classified yet."

REF

REV,FAG "Board PG &: BBA, 953, 214-217, 1988
MEB,FOG,EXP,FAG "Board PG, Webb: PNAS, 84, N8, 2377-2381, 1987
MEB,FOG,EXP "Board PG: AJHG, 33, 36-43, 1981a
PAT,MEB,LIN "Board PG: FEBS Lett, 135, 12-14, 1981b
REV,MEB,FUN,EXP "Campbell EA: Einstein Quart J Biol Med, 8, N4, 106-115, 1990
REV,FAG "Chow NW &: JBC, 263, N26, 12797-12800, 1988
CLO,CYG,MOL,POL "DeJong JL &: CCG, 51, (HGM10), 986, 1989
LOC,FAG,EXP "DeJong JL &: NAR, 16, N17, 8541-8554, 1988
MEB,FOG,EXP,FAG "Harada &: Hum Genet, 75, 322-325, 1987
LOC,FAG,EXP "Islam MQ &: Hum Genet, 82, 338-342, 1989
REV "Laisney V &: Hum Genet, 68, N3, 221-227, 1984
LOC,CYG "Laisney V &: Ann Genet, 26, 69-74, 1983
PAT,MEB,LIN "Levi &: Lancet, 2, 139-140, 1969
REV "Mannervik B &: PNAS, 82, N21, 7202-7206, 1985a
REV "Mannervik B: Adv Enzymol Relat Areas Mol Biol, 57, 357-417, 1985b
MEB,FOG,EXP "Scott, Wright: AJHG, 32, 115-117, 1980
PAT,MEB,LIN "Seidegard &: Carcinogenesis, 7, 751-753, 1986
LOC,CYG "Silberstein DL &: CCG, 32, (HGM6), 317, 1982a
LOC,CYG "Silberstein DL, Shows: Somat Cell Genet, 8, N5, 667-675, 1982b
MEB,EXP,FAG "Strange &: BBA, 993, 186-190, 1989
MEB,FOG,EXP,FAG "Strange &: Biochem Genet, 23, 1011-1028, 1985
MEB,FOG,EXP,FAG "Strange &: Ann Hum Genet, 48, 11-20, 1984
MEB,FOG,EXP,FAG "Suzuki &: Ann Hum Genet, 51, 95-106, 1987
LOC,CYG "Suzuki, Board: Somat Cell Mol Genet, 10, N3, 319-320, 1984

Смотрите также:

  • Глутатион-S-трансфераза (GST)