Gene family: heterogeneous nuclear ribonucleoproteins; (HNRPA1 HNRPA1L HNRPA2B1 HNRPAB HNRPC HNRPF HNRPH1 HNRPH2 HNRPH2P HNRPH3 HNRPI HNRPK HNRPL HNRPM HNRPU PCBP1 PCBP2)

SUM

[1] The RNAs found in the nucleus include pre-mRNAs, mature mRNAs, and intermediate reaction products. Collectively these RNAs are termed heterogeneous nuclear RNAs (hnRNAs). Ribonucleoprotein (RNP) complexes consist of hnRNAs and associated proteins. [2] Heterogeneous nuclear ribonucleoproteins (hnRNPs) associate with nascent RNA polymerase II transcripts (FAM:POLR2/00.0) to form hnRNP complexes and are thought to influence the structure of hnRNA and to participate in pre-mRNA processing. [3] The splicing of pre-mRNA into the mature product occurs in a multicomponent complex constituted by small nuclear ribonucleoprotein particles (snRNP; FAM:SNRP/00.0) and proteins such as splicing factors (see FAM:SFRS/00.0) and heterogeneous nuclear ribonucleoprotein particles (hnRNP). The latter are supposed to code for about 20 different proteins, their MM varying from 34kD to 120kD."