Gene family: heat shock proteins; (HSPA1A HSPA1B HSPA1L HSPA2 HSPA3 HSPA4 HSPA5 HSPA6 HSPA7 HSPA8 HSPA9 HSPAP1 HSPB1 HSPB2 HSPBL1 HSPBL2 HSPBL3 HSPBL4 HSPCA HSPCAL1 HSPCAL2 HSPCAL3 HSPCAL4 HSPCB HSPD1 HSPDP1 HSPDP2 HSPDP3 HSPDP4 HSPDP5 HSPDP6 HSPE1)

FAG

[1] Presently, three heat shock protein classes are distinguished: low-molecular polypeptides (MM no more than 30 kD; class B); middle-molecular polypeptides (MM about 70 kD; class A); and high-molecular polypeptides (MM up to 100 kD; class C). The alphabetic order of designation does not correspond to the order of MMs, because the designation follows the chronology of mapping and cloning of the respective genes: those for 90-kD (refined data, 89 kD) peptides were the last to be cloned. It is supposed that another class heat shock proteins, chaperonins (class D), will be mapped in the nearest future. [2] Twelve loci related to heat shock peptide A genes have been identified. Ten of them are coding genes (GEM:06p2133/HSPA1A; GEM:06p2133/HSPA1B; GEM:14q22/HSPA2; GEM:21^/HSPA3; GEM:05q31/HSPA4; GEM:09q34/HSPA5; GEM:01q/HSPA6; GEM:01q/HSPA7; GEM:11q2/HSPA8; GEM:05q311/HSPA9); one is definitely an A pseudogene (GEM:0X^/HSPAP1); and one else, an A1-like gene (GEM:06p2133/HSPA1L), has been mapped close to the coding A1A and A1B gene. [3] As for three B genes, it is not clear yet, which of them are expressed and which are pseudogenes. MIM Catalogue has no registered these markers (it just mentions them as a class of 27-kD HS peptides, while describing 89-kD peptides under MIM:140571). In addition to B-like gene 1 in Chr 3, three other HSPB-like genes are mapped to Chrs 9q, X, and 5q11.2 (GEM:03^/HSPBL1; GEM:09q/HSPBL2; GEM:0X^/HSPBL3; GEM:05q112/HSPBL4). [4] For class 3 (MM 89 kD) HSPC peptides, cDNAs were identified. Four HSPCA-like sequences were mapped (GEM:01q2/HSPCAL1; GEM:04q35/HSPCAL2; GEM:11p14/HSPCAL3; GEM:14q323/HSPCAL4). The coding alpha sequence is not mapped yet (GEM:00.0/HSPCA); beta polypeptide is mapped to Chr 6 (GEM:06p12/HSPCB)."

REF

REV,FUN,EVO "Burdon RH: Endeavour, 12, (New Ser), N3, 133-138, 1988 SUM,LOC,FAG "McGuire SE &: Somat Cell Mol Genet, 15, 167-171, 1989