Gene: [MHC2/06p2133] major histocompatibility complex, class II polypeptides; (HLADRA HLADRB1 HLADRB1L HLADRB2 HLADRB2P HLADRB3 HLADRB4 HLADRB5 HLADRB6 HLADRB7 HLADRB8 HLADRB9 HLADMA HLADMB HLADQA1 HLADQB1 HLADVB HLADQA2 HLADQB2 HLADQB3 HLADOB HLADNA HLADPA1 HLADPB1 HLADPAP HLADPB2)

SUM	The MHC2 (HLA-D) gene products play a central role in the immune response by presenting exogenous peptides to CD4(+)-T-lymphocytes. In man, six different MHC2-subfamilies have been identified. With the exception of DN and DO all MHC2-subfamilies consist of one or more alpha and beta chains, which are highly polymorphed (except for DRA and DPA1) and expressed as heterodimers."
GEN	On the basis of comparison of HLA-D gene organizations it was concluded that all alpha genes are composed of 5 exons and all beta genes of 6 exons, and that the intron/exon boundary classes of exons 1-4 in alpha genes and exons 1-5 in beta genes are 100% conserved. Only the last boundary class, which falls within the cytoplasmic domain, appears to be variable (Radley-1994)."
REF	PRO,POL,LIN,STR,EXP "Begovich AB &: J Immunol, 148, N1, 249-258, 1992 REV,FUN,EXP,LIN "Neefjes JJ, Momburg F: Curr Opin Immunol, 5, 27-34, 1993 GEN,SEQ,EVO "Radley E &: JBC, 269, 18834-18838, 1994 ENG,EXP "Zwirner &: J Immunol, 148, N1, 272-276, 1992