Gene: [TCR1GV/07p15] T cell receptor, Ti-gamma subunit, VAR-region; (TCR1GV1P TCR1GV2 TCR1GV3 TCR1GV4 TCR1GV5 TCR1GV5P TCR1GV6P TCR1GV7P TCR1GV8 TCR1GV9 TCR1GV9P TCR1GV10 TCR1GVTP TCR1GV11)


SUM

Forster-1987 and Huck-1988 subdivided phylogenetically related VAR minigenes of T cell receptor Ti-gamma subunit into the following groups: group I, genes (and pseudogenes) 1-8; group II, psi-A and V9; group III, V10 and psi-B; group IV, only one gene V11. This subdivision was made by analogy with the subdivision of multiple VAR minigenes of H- and L-kappa immunoglobulin subunits into homology groups (I-IV and more) (see FAM:IGHV/14q3233 and FAM:IGKV/02p12). Within the groups, individual copies of V genes are located almost precisely 5 kb from one another; 12 of the 14 copies (except for V9 and V11) contain a KpnI site."

MAF

The order of V-minigenes at the physical map is ...5'-..V1P-V2-V3-V4..V5..V5P-V6P-V7P-V8--V9P-V9..V10-V1OP-V11..-3'..; the 3'-end of the group borders with the tandem of J and C genes of the TCR1G cluster."

REL

See FAM:TCR1G/07p15.

REF

CLO,SEQ,EXP,LOC,MAF "Forster A &: EMBO J, 6, N7, 1945-1950, 1987
CLO,SEQ,EXP,LOC,MAF "Huck S &: EMBO J, 7, N3, 719-726, 1988
CLO,SEQ,EXP,LOC,MAF "see also GEM:07p15/TCR1GC1 & FAM:TCR1G/07p15