Gene family: T3/CD3 component of T cell receptor complex; (@TCR2DEG TCR2W TCR2Z)
|
GEN |
See FAM:TCR/00.0. |
|
MOP |
[1] The T3 component of T cell TiT3 receptor complex is likely to be a
trimer noncovalently associated with the transmembrane domain of the
Ti component. Four different polypeptides that are capable of forming
the T3 component are identified: gamma, delta, epsilon, and zeta (some
authors refer to the latter as eta); one more peptide, omega, is
assigned to this group conventionally, on the basis of its associating
with the T3 component in the course of its assembling in the
endoplasmic reticulum.
[2] T3 component polypeptides, in contrast to Ti ones, do not belong to the immunoglobulin multigene family and are not subdivided into constant and variable structural domains that would be typical for IMM family." |
|
FAG |
Three TCR2 genes (D, E, and G) form a cluster in chr 11
(FAM:TCR2DEG/11q233). The gene for zeta peptide is located in chr 1q
(01q2/TCR2Z). Gene for omega peptide is not mapped yet (GEM:00.0/TCR2W)." |
|
NOM |
HGM and MIM Catalogues designate the genes for T3 component peptides as CD3 (T3). GEM Catalogue has assigned them the common symbol TCR2, with additional character D, E, G, O, or Z." |
|
REL |
See FAM:TCR/00.0. |
|
REF |
MAF "Saito H &: PNAS, 84, N24, 9131-9134, 1987 MAF "Tunnacliffe A &: Eur J Immunol, 18, 1639-1642, 1988 MAF "Tunnacliffe A &: EMBO J, 6, 2953-2957, 1987 |
