HGNC Approved Gene Symbol: ARF5
Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:127,588,411-127,591,700 (from NCBI)
ADP-ribosylation factors (ARFs) are guanine nucleotide-binding proteins, approximately 20 kD in size, that serve as GTP-dependent allosteric activators of cholera toxin ADP-ribosyltransferase activity (summary by Tsuchiya et al., 1991).
To the 4 species of mammalian ARF, termed ARF1-4, previously identified by cloning, Tsuchiya et al. (1991) added new ARF-like genes, ARF5 and 6 (600464), encoding proteins of 180 and 175 amino acids, respectively. Both proteins contain consensus sequences believed to be involved in guanine nucleotide binding and GTP hydrolysis. ARF5 was more similar in deduced amino acid sequence to ARF4, which also has 180 amino acids.
McGuire et al. (1997) determined that the ARF5 gene contains 6 coding exons spanning approximately 3.2 kb of genomic DNA.
McGuire et al. (1997) mapped the ARF5 gene to a YAC contig on chromosome 7q31.3.
McGuire, R. E., Daiger, S. P., Green, E. D. Localization and characterization of the human ADP-ribosylation factor 5 (ARF5) gene. Genomics 41: 481-484, 1997. [PubMed: 9169151] [Full Text: https://doi.org/10.1006/geno.1997.4689]
Tsuchiya, M., Price, S. R., Tsai, S.-C., Moss, J., Vaughan, M. Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. J. Biol. Chem. 266: 2772-2777, 1991. [PubMed: 1993656]