HGNC Approved Gene Symbol: ARF3
Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:48,935,723-48,957,487 (from NCBI)
For general information on ADP-ribosylation factors, see 103180.
Bobak et al. (1989) identified an ARF3 cDNA from a human cerebellum library.
Tsai et al. (1991) isolated and characterized the human ARF3 gene. They also showed that two ARF3 mRNAs of 3.7 and 1.2 kb are generated through the use of alternative polyadenylation signals.
Tsai et al. (1991) found that the ARF3 gene spans approximately 18.3 kb and contains 5 exons. They found multiple transcription start sites and determined that the conserved amino acid sequences involved in guanine nucleotide binding by ARF3 are distributed among separate exons.
By PCR screening of a somatic cell hybrid panel and fluorescence in situ hybridization, Hirai et al. (1996) mapped the ARF3 gene to 12q13.
Bobak, D. A., Nightingale, M. S., Murtagh, J. J., Price, S. R., Moss, J., Vaughan, M. Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin. Proc. Nat. Acad. Sci. 86: 6101-6105, 1989. [PubMed: 2474826] [Full Text: https://doi.org/10.1073/pnas.86.16.6101]
Hirai, M., Kusuda, J., Hashimoto, K. Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively. Genomics 34: 263-265, 1996. [PubMed: 8661066] [Full Text: https://doi.org/10.1006/geno.1996.0283]
Tsai, S.-C., Haun, R. S., Tsuchiya, M., Moss, J., Vaughan, M. Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding protein activator of cholera toxin. J. Biol. Chem. 266: 23053-23059, 1991. [PubMed: 1744102]