HGNC Approved Gene Symbol: ADH6
Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,202,639-99,219,246 (from NCBI)
Yasunami et al. (1991) used cross-hybridization with an ADH2 (ADH1B; 103720) cDNA probe and screening of PCR-amplified libraries to isolate ADH6. The deduced protein contains 368 amino acids. They identified a glucocorticoid response element at the 5-prime region. The transcript was detected in stomach and liver. The ADH6 sequence shows approximately 60% positional identity with known human ADHs, suggesting interclass similarity within the human ADH family.
Yasunami et al. (1991) determined that the ADH6 gene contains 8 exons spanning about 17 kb.
As outlined by Osier et al. (2002) and others, 7 genes encoding ADH enzymes are located in a cluster extending approximately 380 kb on chromosome 4q. The class I ADH genes, ADH1A (103700), ADH1B, and ADH1C (103730), exist in a tighter cluster of approximately 77 kb, flanked upstream by ADH7 (600086) and downstream by ADH6, ADH4 (103740), and ADH5 (103710), in that order.
Osier, M. V., Pakstis, A. J., Soodyall, H., Comas, D., Goldman, D., Odunsi, A., Okonofua, F., Parnas, J., Schulz, L. O., Bertranpetit, J., Bonne-Tamir, B., Lu, R.-B., Kidd, J. R., Kidd, K. K. A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am. J. Hum. Genet. 71: 84-99, 2002. [PubMed: 12050823] [Full Text: https://doi.org/10.1086/341290]
Yasunami, M., Chen, C.-S., Yoshida, A. A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme. Proc. Nat. Acad. Sci. 88: 7610-7614, 1991. [PubMed: 1881901] [Full Text: https://doi.org/10.1073/pnas.88.17.7610]