Alternative titles; symbols
HGNC Approved Gene Symbol: SLC7A1
Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:29,509,414-29,595,688 (from NCBI)
Susceptibility to murine ecotropic retroviruses is attributed to the binding of the virus envelope to the membrane receptor encoded by the Rec1 gene. Rec1 was identified as the principal transporter of the cationic amino acids arginine, lysine, and ornithine in mouse cells (Kim et al., 1991). Albritton et al. (1992) a human cDNA with homology to mouse Rec1.
Bhattacharyya et al. (2006) found that endogenous CAT1 mRNA was translationally repressed by miR122 (MIR122A; 609582) in Huh7 human hepatoma cells. CAT1 mRNA and reporters bearing its 3-prime UTR could be relieved from miR122-mediated repression by subjecting Huh7 cells to different stress conditions. This derepression was accompanied by release of CAT1 mRNA from cytoplasmic processing bodies and its entry into polysomes, and this process involved binding of HuR (ELAVL1; 603466) to the 3-prime UTR of CAT1.
Oie et al. (1978), Ruddle et al. (1978), and Kozak et al. (1990) mapped the Rec1 gene to mouse chromosome 5 by analysis of murine-hamster somatic cell hybrids. Using a human cDNA obtained by homology to Rec1, Albritton et al. (1992) determined the location of the human cationic amino acid transporter by somatic cell genetics, in situ hybridization, and RFLP linkage analysis. The studies indicated that ATRC1 is located at chromosome 13q12-q14, closely linked to ATP1AL1 (182360). The CEPH consortium linkage map of chromosome 13 published by Bowcock et al. (1993) showed ATRC1 to be distal to ATP1AL1.
Albritton, L. M., Bowcock, A. M., Eddy, R. L., Morton, C. C., Tseng, L., Farrer, L. A., Cavalli-Sforza, L. L., Shows, T. B., Cunningham, J. M. The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14. Genomics 12: 430-434, 1992. [PubMed: 1348489] [Full Text: https://doi.org/10.1016/0888-7543(92)90431-q]
Bhattacharyya, S. N., Habermacher, R., Martine, U., Closs, E. I., Filipowicz, W. Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell 125: 1111-1124, 2006. [PubMed: 16777601] [Full Text: https://doi.org/10.1016/j.cell.2006.04.031]
Bowcock, A. M., Gerken, S. C., Barnes, R. I., Shiang, R., Jabs, E. W., Warren, A. C., Antonarakis, S., Retief, A. E., Vergnaud, G., Leppert, M., Lalouel, J.-M., White, R. L., Cavalli-Sforza, L. L. The CEPH consortium linkage map of human chromosome 13. Genomics 16: 486-496, 1993. [PubMed: 8314586] [Full Text: https://doi.org/10.1006/geno.1993.1215]
Kim, J. W., Closs, E. I., Albritton, L. M., Cunningham, J. M. Transport of cationic amino acids by the mouse ecotropic retrovirus receptor. Nature 352: 725-728, 1991. [PubMed: 1652100] [Full Text: https://doi.org/10.1038/352725a0]
Kozak, C. A., Albritton, L. M., Cunningham, J. M. Genetic mapping of a cloned sequence responsible for susceptibility to ecotropic murine leukemia viruses. J. Virol. 64: 3119-3121, 1990. [PubMed: 2159567] [Full Text: https://doi.org/10.1128/JVI.64.6.3119-3121.1990]
Oie, H. K., Gazdar, A. F., Lalley, P. A., Russell, E. K., Minna, J. D., DeLarco, J., Todaro, G. J., Francke, U. Mouse chromosome 5 codes for ecotropic murine leukaemia virus cell-surface receptor. Nature 274: 60-62, 1978. [PubMed: 566388] [Full Text: https://doi.org/10.1038/274060a0]
Ruddle, N. H., Conta, B. S., Leinwand, L., Kozak, C., Ruddle, F., Besmer, P., Baltimore, D. Assignment of the receptor for ecotropic murine leukemia virus to mouse chromosome 5. J. Exp. Med. 148: 451-465, 1978. [PubMed: 212501] [Full Text: https://doi.org/10.1084/jem.148.2.451]