Alternative titles; symbols
HGNC Approved Gene Symbol: ANXA3
Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:78,551,770-78,610,447 (from NCBI)
ANXA3 is a member of a family of calcium-dependent phospholipid-binding proteins. Annexin III was first identified as inositol 1,2-cyclic phosphate 2-phosphohydrolase (EC 3.1.4.36), an enzyme of inositol phosphate metabolism, and also as placental anticoagulant protein III, lipocortin III, calcimedin 35-alpha, and an abundant neutrophil cytoplasmic protein (summary by Tait et al., 1991).
Tait et al. (1988) and Pepinsky et al. (1988) found that the mature annexin III protein contains 322 amino acids and, like other annexins, consists primarily of 4 copies of a 70- to 80-amino acid repeat unit. By Northern blot analysis, Tait et al. (1993) detected a single ANXA3 mRNA species of approximately 1.7 kb in all tissues tested.
Tait et al. (1993) determined that the ANXA3 gene contains 13 exons and spans 58 kb of genomic DNA.
Tait et al. (1991) localized the ANXA3 gene to 4q21 (q13-q22) by PCR analysis of a human-rodent hybrid cell panel, confirmed by genomic Southern blot analysis of the same panel with a cDNA probe, and by in situ hybridization with a cDNA probe.
Pepinsky, R. B., Tizard, R., Mattaliano, R. J., Sinclair, L. K., Miller, G. T., Browning, J. L., Chow, E. P., Burne, C., Huang, K.-S., Pratt, D., Wachter, L., Hession, C., Frey, A. Z., Wallner, B. P. Five distinct calcium and phospholipid binding proteins share homology with lipocortin I. J. Biol. Chem. 263: 10799-10811, 1988. [PubMed: 2968983]
Tait, J. F., Frankenberry, D. A., Miao, C. H., Killary, A. M., Adler, D. A., Disteche, C. M. Chromosomal localization of the human annexin III (ANX3) gene. Genomics 10: 441-448, 1991. [PubMed: 1830024] [Full Text: https://doi.org/10.1016/0888-7543(91)90330-h]
Tait, J. F., Sakata, M., McMullen, B. A., Miao, C. H., Funakoshi, T., Hendrickson, L. E., Fujikawa, K. Placental anticoagulant proteins: isolation and comparative characterization of four members of the lipocortin family. Biochemistry 27: 6268-6276, 1988. [PubMed: 2975506] [Full Text: https://doi.org/10.1021/bi00417a011]
Tait, J. F., Smith, C., Xu, L., Cookson, B. T. Structure and polymorphisms of the human annexin III (ANX3) gene. Genomics 18: 79-86, 1993. [PubMed: 8276419] [Full Text: https://doi.org/10.1006/geno.1993.1428]