Alternative titles; symbols
HGNC Approved Gene Symbol: ANXA4
Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:69,643,808-69,827,112 (from NCBI)
The annexins, or lipocortins, are a family of calcium-dependent phospholipid-binding proteins whose normal function is uncertain. Annexin IV, otherwise known as placental anticoagulant protein II, was 1 of the 4 annexins isolated from human placenta on the basis of their in vitro anticoagulant activity. Grundmann et al. (1988) reported a cDNA clone for annexin IV. Hauptmann et al. (1989) showed that annexin IV has 45 to 59% identity with other members of the annexin family.
Fukuoka et al. (2002) found that rat Anxa4, which they called Zap36, was ubiquitously expressed in epithelial tissues. In dog and rat pancreas, Zap36 associated with zymogen granule membranes.
By genomic Southern blotting with a cDNA probe, Tait et al. (1992) determined that the ANXA4 gene spans 18 to 56 kb. DNA sequence analysis demonstrated a single intron with exon-intron boundaries in exactly the same position as in the mouse annexin I and annexin II genes.
By PCR analysis of somatic cell hybrids and in situ hybridization with a cDNA probe, Tait et al. (1992) mapped the human ANXA4 gene to chromosome 2p13. Barrow et al. (1994) demonstrated that the Anxa4 gene is located on mouse chromosome 6 in a region of conserved synteny with human chromosome 2.
Barrow, L. L., Simin, K., Jones, J. M., Lee, D. C., Meisler, M. H. Conserved linkage of early growth response 4, annexin 4, and transforming growth factor alpha on mouse chromosome 6. Genomics 19: 388-390, 1994. [PubMed: 8188273] [Full Text: https://doi.org/10.1006/geno.1994.1078]
Fukuoka, S.-I., Kern, H., Kazuki-Sugino, R., Ikeda, Y. Cloning and characterization of ZAP36, an annexin-like, zymogen granule membrane associated protein, in exocrine pancreas. Biochim. Biophys. Acta 1575: 148-152, 2002. [PubMed: 12020832] [Full Text: https://doi.org/10.1016/s0167-4781(02)00299-3]
Grundmann, U., Amann, E., Abel, K.-J., Kupper, H. A. Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family. Behring Inst. Mitt. 82: 59-67, 1988.
Hauptmann, R., Maurer-Fogy, I., Krystek, E., Bodo, G., Andree, H., Reutelingsperger, C. P. M. Vascular anticoagulant beta, a novel human Ca(2+)/phospholipid binding protein that inhibits coagulation and phospholipase A-2 activity: its molecular cloning, expression and comparison with VAC-alpha. Europ. J. Biochem. 185: 63-71, 1989. [PubMed: 2530088] [Full Text: https://doi.org/10.1111/j.1432-1033.1989.tb15082.x]
Tait, J. F., Smith, C., Frankenberry, D. A., Miao, C. H., Adler, D. A., Disteche, C. M. Chromosomal mapping of the human annexin IV (ANX4) gene. Genomics 12: 313-318, 1992. [PubMed: 1346776] [Full Text: https://doi.org/10.1016/0888-7543(92)90379-7]