Entry - 108990 - ATTACHED CELL ANTIGEN 28.3.7; MIC7 - OMIM

 
 
108990

ATTACHED CELL ANTIGEN 28.3.7; MIC7



TEXT

▼ Cloning and Expression

Human cells growing in vitro attached to the substratum express a cell antigen called 28.3.7 identified by a species-specific monoclonal antibody. This antigen is not expressed on cells growing in suspension. The antigen has a molecular weight of 95,000. The gene is symbolized MIC7 (for monoclonal and Imperial Cancer, the laboratory where it was identified, plus 7 for the sequential monoclonal in that laboratory). The antigen is a marker for macrophage differentiation (Blaineau et al., 1983).


▼ Mapping

The MIC7 gene maps to human chromosome 15, according to the results of somatic cell hybrid studies (Blaineau et al., 1983).


▼ REFERENCES

  1. Blaineau, C., Avner, P., Tunnacliffe, A., Goodfellow, P. 'Attached cell' antigen 28.3.7 mapping to human chromosome 15 characterises TPA-induced differentiation of the promyelocytic HL-60 cell line to give macrophage/monocyte populations. EMBO J. 2: 2007-2012, 1983. [PubMed: 6641710, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 6/4/1986
Edit History:
carol : 02/24/2020
alopez : 07/16/2012
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/26/1989
marie : 3/25/1988
reenie : 6/4/1986

108990

ATTACHED CELL ANTIGEN 28.3.7; MIC7



TEXT

Cloning and Expression

Human cells growing in vitro attached to the substratum express a cell antigen called 28.3.7 identified by a species-specific monoclonal antibody. This antigen is not expressed on cells growing in suspension. The antigen has a molecular weight of 95,000. The gene is symbolized MIC7 (for monoclonal and Imperial Cancer, the laboratory where it was identified, plus 7 for the sequential monoclonal in that laboratory). The antigen is a marker for macrophage differentiation (Blaineau et al., 1983).


Mapping

The MIC7 gene maps to human chromosome 15, according to the results of somatic cell hybrid studies (Blaineau et al., 1983).


REFERENCES

  1. Blaineau, C., Avner, P., Tunnacliffe, A., Goodfellow, P. 'Attached cell' antigen 28.3.7 mapping to human chromosome 15 characterises TPA-induced differentiation of the promyelocytic HL-60 cell line to give macrophage/monocyte populations. EMBO J. 2: 2007-2012, 1983. [PubMed: 6641710] [Full Text: https://doi.org/10.1002/j.1460-2075.1983.tb01692.x]


Creation Date:
Victor A. McKusick : 6/4/1986

Edit History:
carol : 02/24/2020
alopez : 07/16/2012
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/26/1989
marie : 3/25/1988
reenie : 6/4/1986



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 2, 2024