Alternative titles; symbols
HGNC Approved Gene Symbol: CALCB
Cytogenetic location: 11p15.2 Genomic coordinates (GRCh38): 11:15,073,593-15,078,637 (from NCBI)
The calcitonin gene (CALCA; 114130) is alternatively expressed in a tissue-specific fashion producing either the calcium regulatory hormone calcitonin or the neuropeptide CGRP (calcitonin gene-related peptide). Both CT and CGRP are produced in medullary carcinoma of the thyroid. By Southern blot analysis of DNA from human rodent somatic cell hybrids, Hoppener et al. (1985) assigned the CALC2 gene to 11pter-q12. By alternative RNA processing events, a single rat (and presumably human) gene can generate mRNAs encoding either calcitonin or a neuropeptide referred to as alpha-type calcitonin gene-related peptide (alpha-CGRP). Amara et al. (1985) identified in rat brain and thyroid an mRNA product of a related gene that differs from alpha-CGRP by only a single amino acid. The RNA encoding this peptide, called beta-CGRP, appeared to be the only mature transcript of the beta-CGRP gene. Hoovers et al. (1993) demonstrated that the CALCB gene is in the same 220-kb SacII fragment as CALCA.
Amara, S. G., Arriza, J. L., Leff, S. E., Swanson, L. W., Evans, R. M., Rosenfeld, M. G. Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide. Science 229: 1094-1097, 1985. [PubMed: 2994212] [Full Text: https://doi.org/10.1126/science.2994212]
Hoovers, J. M. N., Redeker, E., Speleman, F., Hoppener, J. W. M., Bhola, S., Bliek, J., van Roy, N., Leschot, N. J., Westerveld, A., Mannens, M. High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members. Genomics 15: 525-529, 1993. [PubMed: 8468047] [Full Text: https://doi.org/10.1006/geno.1993.1104]
Hoppener, J. W. M., Steenbergh, P. H., Zandberg, J., Geurts van Kessel, A. H. M., Baylin, S. B., Nelkin, B. D., Jansz, H. S., Lips, C. J. M. The second human calcitonin/CGRP gene is located on chromosome 11. Hum. Genet. 70: 259-263, 1985. [PubMed: 2991116] [Full Text: https://doi.org/10.1007/BF00273453]
Steenbergh, P. H., Hoppener, J. W. M., Zandberg, J., Lips, C. J. M., Jansz, H. S. A second human calcitonin/CGRP gene. FEBS Lett. 183: 403-407, 1985. [PubMed: 2985435] [Full Text: https://doi.org/10.1016/0014-5793(85)80820-6]