Alternative titles; symbols
HGNC Approved Gene Symbol: CHGB
Cytogenetic location: 20p12.3 Genomic coordinates (GRCh38): 20:5,911,510-5,925,353 (from NCBI)
Chromogranin B (secretogranin I) is a tyrosine-sulfated secretory protein found in a wide variety of peptidergic endocrine cells. Benedum et al. (1987) isolated a 2.5-kb cDNA clone from a cDNA library of human pheochromocytoma. Chromogranin B is a 657-amino acid polypeptide of 76 kilodaltons preceded by a cleaved end-terminal signal peptide of 20 residues.
Craig et al. (1986) assigned the chromogranin B gene to chromosome 20. Craig et al. (1987) showed by in situ hybridization that the CHGB locus is on 20pter-p12. Jenkins et al. (1991) mapped the murine gene, symbolized Scg-1, to chromosome 2 by in situ hybridization and by interspecific backcross analysis.
Benedum, U. M., Lamouroux, A., Konecki, D. S., Rosa, P., Hille, A., Baeuerle, P. A., Frank, R., Lottspeich, F., Mallet, J., Huttner, W. B. The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region. EMBO J. 6: 1203-1211, 1987. [PubMed: 3608978] [Full Text: https://doi.org/10.1002/j.1460-2075.1987.tb02355.x]
Craig, S. P., Lamouroux, A., Mallet, J., Huttner, W., Craig, I. W. Localisation of the gene for chromogranin B to chromosome 20. (Abstract) 7th Int. Cong. Hum. Genet., Berlin 1986.
Craig, S. P., Lamouroux, A., Mallet, J., Huttner, W., Craig, I. W. Localisation of the human gene for secretogranin 1 (chromogranin B) to chromosome 20. (Abstract) Cytogenet. Cell Genet. 46: 600 only, 1987.
Jenkins, N. A., Mattei, M.-G., Gilbert, D. J., Linard, C. G., Mbikay, M., Chretien, M., Copeland, N. G. Assignment of secretogranin I locus to mouse chromosome 2 by in situ hybridization and interspecific backcross analysis. Genomics 11: 479-480, 1991. [PubMed: 1685143] [Full Text: https://doi.org/10.1016/0888-7543(91)90165-b]