Alternative titles; symbols
HGNC Approved Gene Symbol: PPIC
Cytogenetic location: 5q23.2 Genomic coordinates (GRCh38): 5:123,023,250-123,036,725 (from NCBI)
Cyclophilins catalyze the cis-trans isomerization of peptidyl-prolyl bonds, a rate-limiting step in protein folding. Members of the cyclophilin family bind the immunosuppressive drug cyclosporin A (CsA) and share a conserved core domain of approximately 110 amino acids, called the cyclophilin domain.
Friedman and Weissman (1991) cloned cyclophilin C from a cDNA library prepared from a murine bone marrow-derived stromal cell line. Their initial interest in the cDNA was based on its high level of homology with all known cyclophilins. The tissue distribution made it a candidate for the mediator of the immunosuppressive and nephrotoxic actions of cyclosporin A, as it is expressed most highly in the kidney and can be detected in activated T cells. Liu et al. (1991) presented evidence that calcineurin (114105) is involved in a common step associated with T-cell receptor and IgE receptor signaling pathways and that cyclophilin and FKBP (186945) mediate the actions of CsA and FK506, respectively, by forming drug-dependent complexes with and altering the activity of calcineurin-calmodulin.
Stumpf (2022) mapped the PPIC gene to chromosome 5q23.2 based on an alignment of the PPIC sequence (GenBank BC002678) with the genomic sequence (GRCh38).
Friedman, J., Weissman, I. Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA. Cell 66: 799-806, 1991. [PubMed: 1652374] [Full Text: https://doi.org/10.1016/0092-8674(91)90123-g]
Liu, J., Farmer, J. D., Jr., Lane, W. S., Friedman, J., Weissman, I., Schreiber, S. L. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66: 807-815, 1991. [PubMed: 1715244] [Full Text: https://doi.org/10.1016/0092-8674(91)90124-h]
Stumpf, A. M. Personal Communication. Baltimore, Md. 08/15/2022.