Alternative titles; symbols
HGNC Approved Gene Symbol: EGR4
Cytogenetic location: 2p13.2 Genomic coordinates (GRCh38): 2:73,290,929-73,293,548 (from NCBI)
NGFIC is a nerve growth factor-induced early response gene that encodes a C2/H2 zinc finger protein (Crosby et al., 1992).
Crosby et al. (1992) cloned the NGFIC gene, which encodes a predicted 478-amino acid protein containing 3 zinc fingers of the C2/H2 subtype near the carboxy terminus.
By use of fluorescence in situ hybridization, Crosby et al. (1992) localized the human EGR4 gene to 2p13. Barrow et al. (1994) demonstrated that the homologous gene in the mouse (Egr4) maps to chromosome 6 in a region of conserved homology of synteny with human chromosome 2.
Barrow, L. L., Simin, K., Jones, J. M., Lee, D. C., Meisler, M. H. Conserved linkage of early growth response 4, annexin 4, and transforming growth factor alpha on mouse chromosome 6. Genomics 19: 388-390, 1994. [PubMed: 8188273] [Full Text: https://doi.org/10.1006/geno.1994.1078]
Crosby, S. D., Veile, R. A., Donis-Keller, H., Baraban, J. M., Bhat, R. V., Simburger, K. S., Milbrandt, J. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. Proc. Nat. Acad. Sci. 89: 4739-4743, 1992. Note: Erratum: Proc. Nat. Acad. Sci. 89: 6663 only, 1992. [PubMed: 1584812] [Full Text: https://doi.org/10.1073/pnas.89.10.4739]