Alternative titles; symbols
HGNC Approved Gene Symbol: FPR3
Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,795,157-51,826,190 (from NCBI)
Bao et al. (1992) identified 2 structural homologs of FMLP receptor (FPR1; 136537), FPRL1 (FPR2; 136538) and FPRL2 (FPR3). Since these 2 structural homologs did not recognize the ligand FMLP, Bao et al. (1992) referred to them as orphan receptors. Nonetheless, they probably function as chemotactic receptors.
By screening organ extracts on cell lines expressing FPRL2, Migeotte et al. (2005) isolated F2L (FPRL2 ligand) from spleen. F2L is an acetylated 21-amino acid peptide derived from the N terminus of intracellular heme-binding protein (HEBP1; 605826). F2L bound and activated FPRL2 in the nanomolar range, triggering intracellular calcium release, inhibition of cAMP accumulation, and phosphorylation of MAP kinases. Testing on monocytes and monocyte-derived dendritic cells showed that F2L promoted calcium mobilization and chemotaxis. Migeotte et al. (2005) concluded that F2L is a natural chemoattractant peptide for dendritic cells and monocytes and is specific for FPRL2.
By somatic cell hybrid analysis, Bao et al. (1992) showed that, like FPR1, FPR2 and FPR3 map to chromosome 19.
Bao, L., Gerard, N. P., Eddy, R. L., Jr., Shows, T. B., Gerard, C. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. Genomics 13: 437-440, 1992. [PubMed: 1612600] [Full Text: https://doi.org/10.1016/0888-7543(92)90265-t]
Migeotte, I., Riboldi, E., Franssen, J.-D., Gregoire, F., Loison, C., Wittamer, V., Detheux, M., Robberecht, P., Costagliola, S., Vassart, G., Sozzani, S., Parmentier, M., Communi, D. Identification and characterization of an endogenous chemotactic ligand specific for FPRL2. J. Exp. Med. 201: 83-93, 2005. [PubMed: 15623572] [Full Text: https://doi.org/10.1084/jem.20041277]