Entry - #136540 - FRAGILE SITE 10q23 - OMIM

 
 
# 136540

FRAGILE SITE 10q23



▼ TEXT

This is a folic acid-sensitive fragile site; that at 10q25 is the unique BrdU-sensitive fragile site. Sutherland et al. (1982) studied 2 families in which the same homolog of chromosome pair 10 expressed both the fragile sites on the long arm at 10q23 and 10q25. Recombination between the fragile sites was observed in 3 of 27 offspring. The genetic length of the interval between the 2 fragile sites was estimated to be 11 female centimorgans (95% probability interval: 4-28 cM). The estimate is comparable to those obtained by other methods.


▼ REFERENCES

  1. Sutherland, G. R., Baker, E., Mulley, J. C. Genetic length of a human chromosomal segment measured by recombination between two fragile sites. Science 217: 373-374, 1982. [PubMed: 7089572, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 6/4/1986
Edit History:
carol : 12/02/2014
carol : 3/30/1992
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/26/1989
marie : 3/25/1988
reenie : 6/4/1986

# 136540

FRAGILE SITE 10q23



TEXT

This is a folic acid-sensitive fragile site; that at 10q25 is the unique BrdU-sensitive fragile site. Sutherland et al. (1982) studied 2 families in which the same homolog of chromosome pair 10 expressed both the fragile sites on the long arm at 10q23 and 10q25. Recombination between the fragile sites was observed in 3 of 27 offspring. The genetic length of the interval between the 2 fragile sites was estimated to be 11 female centimorgans (95% probability interval: 4-28 cM). The estimate is comparable to those obtained by other methods.


REFERENCES

  1. Sutherland, G. R., Baker, E., Mulley, J. C. Genetic length of a human chromosomal segment measured by recombination between two fragile sites. Science 217: 373-374, 1982. [PubMed: 7089572] [Full Text: https://doi.org/10.1126/science.7089572]


Creation Date:
Victor A. McKusick : 6/4/1986

Edit History:
carol : 12/02/2014
carol : 3/30/1992
supermim : 3/16/1992
supermim : 3/20/1990
ddp : 10/26/1989
marie : 3/25/1988
reenie : 6/4/1986



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 5, 2024