Alternative titles; symbols
HGNC Approved Gene Symbol: FUT5
Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,865,826-5,870,540 (from NCBI)
Weston et al. (1992) isolated a human alpha-3-fucosyltransferase gene homologous to but distinct from 2 previously reported fucosyltransferase genes: alpha-3,4-fucosyltransferase, thought to represent the human Lewis blood group locus (FUT3; 111100), and an alpha-3-fucosyltransferase expressed in the myeloid lineage (FUT4; 104230). The new enzyme shared 91% amino acid sequence identity with the Lewis blood group fucosyltransferase, yet exhibited only trace amounts of alpha-4-fucosyltransferase activity. Weston et al. (1992) concluded that the FUT5 gene encodes a 'plasma type' of alpha-3-fucosyltransferase.
By PCR analysis of somatic cell hybrid DNAs, Weston et al. (1992) mapped the FUT5 gene to chromosome 19.
McCurley et al. (1995) mapped FUT5 to 19p13.3 by fluorescence in situ hybridization using cosmids containing FUT6 (136836) and FUT5. The results indicated that FUT6 lies approximately 70 kb telomeric of FUT5. McCurley et al. (1995) used conventional and pulsed field gel electrophoresis mapping to total genomic DNA and large genomic clones to generate a fine map of the cluster of 19p FUT genes. A P1 clone indicated the gene order: cen--FUT5--FUT3--FUT6--tel. FUT5 and FUT3 are separated by 23 kb and FUT3 and FUT6 are separated by 14 kb; these data placed FUT5 and FUT6 closer together than was estimated by fluorescence in situ hybridization. The close proximity and tandem orientation of the 3 genes suggests coordinate regulation. The direction of transcription is toward the telomere in the case of all 3 genes.
McCurley, R. S., Recinos, A., III, Olsen, A. S., Gingrich, J. C., Szczepaniak, D., Cameron, H. S., Krauss, R., Weston, B. W. Physical maps of human alpha(1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. Genomics 26: 142-146, 1995. [PubMed: 7782074] [Full Text: https://doi.org/10.1016/0888-7543(95)80094-3]
Weston, B. W., Nair, R. P., Larsen, R. D., Lowe, J. B. Isolation of a novel human alpha(1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha(1,3/1,4)fucosyltransferase gene: syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities. J. Biol. Chem. 267: 4152-4160, 1992. [PubMed: 1740457]