Alternative titles; symbols
HGNC Approved Gene Symbol: ATP4B
Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,648,804-113,658,198 (from NCBI)
Hydrogen-potassium adenosine triphosphatase (H(+),K(+)-ATPase; EC 3.6.1.36) belongs to a family of P-type cation-transporting ATPases that also includes Ca(2+)-ATPase (108740) and Na(+),K(+)-ATPase (182310). In gastric parietal cells, H(+),K(+)-ATPase plays an essential role in the formation of hydrochloric acid. Like the Na(+),K(+)-ATPase, H(+),K(+)-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit (ATP4A; 137216) and a smaller but heavily glycosylated beta subunit. Reuben et al. (1990) characterized the beta subunit of the gastric hydrogen-potassium ATPase of the rabbit. Homology with the sodium/potassium-ATPase subclass was demonstrated. The beta subunit of hydrogen-potassium ATPase is a major antigen recognized by sera from pernicious anemia and atrophic gastritis patients (Toh et al., 1990).
Canfield et al. (1990) isolated cDNA clones encoding the bovine and rat gastric H(+),K(+)-ATPase beta subunit. Northern and Western blot analysis showed that the gene is expressed exclusively in the stomach. Structural similarities suggested that genes for the beta subunits of H(+),K(+)-ATPase and Na(+),K(+)-ATPase evolved from a common ancestral gene. The cDNA is 1.4 kb long.
Canfield et al. (1990) determined that, in contrast to the 22-exon gene encoding the alpha subunit (ATP4A), the beta subunit of H(+),K(+)-ATPase is encoded by a gene, ATP4B, comprising 7 exons.
By fluorescence in situ hybridization, Song et al. (1992) mapped the human ATP4B gene to chromosome 13q34.
By analyzing the segregation of RFLPs among recombinant inbred strains of mice, Canfield et al. (1990) mapped the gene to mouse chromosome 8.
Canfield, V. A., Okamoto, C. T., Chow, D., Dorfman, J., Gros, P., Forte, J. G., Levenson, R. Cloning of the H,K-ATPase beta subunit: tissue-specific expression, chromosomal assignment, and relationship to Na,K-ATPase beta subunits. J. Biol. Chem. 265: 19878-19884, 1990. [PubMed: 1978834]
Reuben, M. A., Lasater, L. S., Sachs, G. Characterization of a beta subunit of the gastric H(+)/K(+)-transporting ATPase. Proc. Nat. Acad. Sci. 87: 6767-6771, 1990. [PubMed: 2168558] [Full Text: https://doi.org/10.1073/pnas.87.17.6767]
Song, I., Brown, D. R., Yamada, T., Trent, J. M. Mapping of the gene encoding the beta-subunit of H(+), K(+)-ATPase to human chromosome 13q34 by fluorescence in situ hybridization. Genomics 14: 1114-1115, 1992. [PubMed: 1335958] [Full Text: https://doi.org/10.1016/s0888-7543(05)80142-9]
Toh, B.-H., Gleeson, P. A., Simpson, R. J., Moritz, R. L., Callaghan, J. M., Goldkorn, I., Jones, C. M., Martinelli, T. M., Mu, F.-T., Humphris, D. C., Pettitt, J. M., Mori, Y., Masuda, T., Sobieszczuk, P., Weinstock, J., Mantamadiotis, T., Baldwin, G. S. The 60- to 90-kDa parietal cell autoantigen associated with autoimmune gastritis is a beta subunit of the gastric H(+)/K(+)-ATPase (proton pump). Proc. Nat. Acad. Sci. 87: 6418-6422, 1990. [PubMed: 1974721] [Full Text: https://doi.org/10.1073/pnas.87.16.6418]